nadphoxidase

GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1 4抑制剂，Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。

Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu

Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth. After administration of plant extracts containing Horminone has possibility of toxic effect.

Zederone（蓬莪术环氧酮）是一种天然的倍半萜烯，能够调节炎症反应、放松平滑肌和内分泌来治疗痛经；能够下调mTOR和p70s6K的mRNA水平从而抑制卵巢癌细胞增殖，与降糖蛋白3L4Y和5UBA相互作用从而抗糖尿病和抗氧化。

Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。 在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。 在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。

ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM)，对 NOX1 的特异性高于 NOX2、NOX3、NOX4（所有 IC50 > 10 μM）100倍。

gp91 ds-tat 是一种 NADPH 氧化酶（NOX2)抑制剂，可降低 NOX2 表达。

5-Heneicosylresorcinol 对 RBL-2H3 细胞中 β-己糖胺酶的释放具有抑制作用，它还可以防止 3T3-L1 细胞中甘油三酯的积累。它对红线虫、秀丽隐杆线虫和松材线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug mL。

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂，对 Nox1，Nox2和 Nox4的 Ki 分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。

GLX351322 抑制 NADPH 氧化酶 4 (Nox4) 。在 NOX4 过表达的细胞中，抑制过氧化氢的产生，IC50值为 5 μM。

Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.

Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line.

gp91ds-tat 是一种 NADPH 氧化酶(NADPH oxidase)的肽抑制剂，由与人类免疫缺陷病毒-tat 肽相连的 gp91phox 序列组成。tat 序列促进了这种肽进入细胞。

Quercetin-3-O-glucose-6''-acetate (6 -O-Acetylisoquercitrin) 是 NADPH 氧化酶的抑制剂。 Quercetin-3-O-glucose-6''-acetate 具有抗氧化活性。

8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell lines (IC50 = 3.50 microM for HT29

Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal concentration against epimastigotes

Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul

Setanaxib (GKT137831) 是一种有效的特异性双重 NADPH 氧化酶 (NOX1 4) 抑制剂，Ki 分别为140和110nM。

4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion.

8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.

Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter.

Ketoconazole (R-41400) 是一种咪唑类抗真菌剂，也是一种 CYP3A4 抑制剂。

VAS 3947 是一种特异的 NADPH 氧化酶 (NOX) 抑制剂。VAS 3947具有强大的抗血小板作用, 通过 UPR 激活，主要由于蛋白质聚集和错误折叠，独立于抗 NOX 活性诱导细胞凋亡。