monophosphate

Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。

Mycophenolic acid (Mycophenolate) 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂，EC50为 0.24 µM。它对多种 RNA 病毒具有抗病毒作用。它也是一种免疫抑制剂，具有抗血管生成和抗肿瘤作用。

Adefovir 是一种单磷酸腺苷类似物抗病毒剂，在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA 聚合酶。它在 HepG2.2.15 细胞系中对HBV 的IC50为 0.7 μM。它对多种病毒(包括HBV 和疱疹病毒)具有良好的抗病毒活性。

N6-Methyladenosine 5'-monophosphate disodium salt 是糖原磷酸化酶 b 激活剂，也是腺苷酸激酶 II 的抑制剂。

Adenosine-2'-monophosphate (2'-AMP) 是由 2’,3'-CAMP 转化的核苷，抑制小胶质细胞产生炎性细胞因子，通过 A2A 受体抑制活化的原代小鼠小胶质细胞产生 TNF-α 和 CXCL10。

Xanthosine 5'-monophosphate 由IMP通过肌苷-5'-单磷酸酯脱氢酶 (IMPDH) 催化生成。

Gemcitabine monophosphate is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. Gemcitabine monophosphate was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.

substrate of IMP dehydrogenase (IMPDH)

Lyxoflavin 5'-monophosphate binds to flavodoxin.

Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .

2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.

Uridine-3'-monophosphate is a nucleoside used in the biochemical synthesis of ribothymidine-3'-phosphate. It has been used as a bioavailable source of uridine in research studies designed to enhance learning and memory.

Riboflavin 5'-monophosphate (FMN) is a coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways. FMN also binds the FMN riboswitch (RFN element) on RNA to alter gene regulation. FMN is a substrate of FMN phosphohydrolases and is used to study their function.

Ribavirin 5'-monophosphate (lithium salt)对 IMP 脱氢酶（将 IMP 转化为 XMP）具体直接抑制作用

Remdesivir nucleoside monophosphate, a metabolite of Remdesivir, is a potent antiviral compound with nucleoside analogue characteristics. It exhibits effective antiviral activity against both SARS-CoV and MERS-CoV.

Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase.

Acyclovir monophosphate 是抗单纯疱疹病毒 (HSV)剂，并且具有抗肿瘤活性。Acyclovir monophosphate 通过抑制病毒 DNA 聚合酶从而阻断 DNA 合成，同时能终止病毒 DNA 的链延伸。

Inosine-5'-monophosphate Disodium Salt heptahydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67245，CAS号为 849725-39-9。

Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy.

2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium 为嘌呤核苷类似物，主要拥有广泛的抗肿瘤活性，并针对惰性淋巴系统恶性肿瘤。其抗癌作用机制涉及抑制 DNA 合成和诱导细胞凋亡(apoptosis)等过程。

2’-Deoxy-2’-fluoroadenosine 5’-monophosphate (triethylammonium) 是嘌呤核苷类似物，主要应用于靶向惰性淋巴系统恶性肿瘤的抗肿瘤活性研究中。其抗癌机制包括抑制 DNA 合成和诱导细胞凋亡 (apoptosis)，显示出广泛的抗肿瘤效果。

2’-O-Methyladenosine 5’-monophosphate triethyl ammonium 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂，也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate，Acadesine ，Clofarabine ，Fludarabine phosphate 和 Vidarabine 。

2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium 是一种嘌呤核苷类似物，拥有广泛的抗肿瘤活性，特别是对惰性淋巴系统的恶性肿瘤。其抗癌作用机制主要通过抑制 DNA 合成及诱导细胞凋亡（apoptosis）实现。

2’-O,4’-C-Methyleneadenosine 5’-monophosphate (triethylammonium) 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要针对惰性淋巴系统的恶性肿瘤。其作用机制涉及抑制 DNA 合成和诱导细胞凋亡(apoptosis)。