BF-170是一种选择性的tau纤维结合剂,其EC50为221 nM。BF-170具有优越的血脑屏障穿透性,在小鼠静脉注射后2分钟脑组织中的浓度达到9.1% ID g(在30分钟后,脑内清除率为0.25% ID g),可作为阿尔茨海默病(AD)中tau蛋白病理成像的探针。在阿尔茨海默病早期阶段研究中,BF-170具有关键作用,并有潜力用于tau相关神经退行性疾病的成像研究。
AL-8417 is an enzyme inhibitor. It acting as an antioxidant, anti-inflammatory, and cytostatic agent. It also has the ability to suppress vitrectomy-induced posterior lens fiber changes.
Zelpolib is a novel DNA polymerase inhibitor, inhibiting DNA replication in assays to assess global DNA synthesis or single-molecule bases by DNA fiber fluorography.
Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the induction of coughing.
Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber forma
CGGRGD is a RGD derivative with cysteine as the n-terminal. CGGRGD was synthesized by solid phase peptide synthesis technology, and amino2-cyanobenzothiazole (2-cyanobenzothiazole) (2-cyanobenzothiazole (CBT) was added on the surface of PCL fiber for ammo