eif-4e

4E1RCat 是 cap 依赖性翻译抑制剂，可抑制 eIF4 g 与 eIF4E 的结合，IC50 为 3.2 μM。

ATPγS tetralithium salt 是 RNA 刺激的核苷酸水解和 eIF4A 的 RNA 解旋活性的良好底物。

4E2RCat 是一种 eIF4E-eIF4G 相互作用的抑制剂，IC50为13.5 μM。

eIF4E-IN-3 is a highly effective inhibitor of eukaryotic initiation factor 4e (eIF4e), exhibiting noteworthy potential for investigating eIF4e dependent diseases, particularly cancer research (WO2021003157A1, compound 485).

eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases.

eIF4E-IN-2 is a highly effective inhibitor of eukaryotic initiation factor 4e (eIF4e). This compound exhibits significant potential in the investigation of eIF4e dependent diseases, particularly in the context of cancer research.

eIF4E-IN-5（Compound 6n）为细胞渗透性eIF4E抑制剂，能与加帽mRNA结合，从而抑制帽依赖性翻译。

eIF4E-IN-6（化合物4b）是一种针对eIF4E设计的抑制剂，可阻止其与cap mRNA的结合，其化学结构为GMP类似物。该化合物在Caco-2、HepG-2和MCF-7细胞系中显示出细胞毒性效果，其IC50值分别约为31、27和21 μM。

4EGI-1 是一种竞争性 eIF4E eIF4 g 相互作用抑制剂，与 eIF4E 结合，Kd 值为 25 μM。