deacetylated

Norgestimate 是一种具有口服活性、高度选择性的孕激素活性和较小雄激素作用的孕激素，是一种合成的孕激素类似物。它可用作口服的避孕药。

N-deacetylated BMS-202 是 PD-1 PD-L1 相互作用的抑制剂，具有潜在的抗癌活性，可用于研究癌症。

Ganoderic acid D 是高度氧化的四环三萜，是灵芝的主要活性成分，可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸、丙酮酸和乙酰辅酶的产生。

Chitosan (Deacetylated chitin) (≥95% deacetylated, viscosity 100-200 mPa.s) 是一种由甲壳素脱乙酰化而来的多糖，具有对多种细菌和真菌的抗菌活性。

Chitosan hydrochloride 80%-90% deacetylated (Chitosan HCl 80%-90% deacetylated) 是 chitosan 的盐酸盐衍生物。这种80%-90%脱乙酰化的多糖来源于甲壳素，显示出对多种细菌和真菌的抗菌活性。Chitosan hydrochloride 80%-90% deacetylated 在农业、水处理及制药行业中广泛应用。

Chitosan (Deacetylated chitin) (≥90% deacetylated, viscosity 10 mPa.s) 是脱乙酰化的甲壳素多糖，对多种细菌和真菌具有抗菌活性。Chitosan (≥90% deacetylated, viscosity 10 mPa.s) 可作为多功能生物材料，应用于药物输送、组织工程和伤口愈合。

Chitosan (Deacetylated chitin)是一种高纯度生化试剂，适合作为生物材料或有机合成中间体，广泛应用于生命科学领域的研究与实验。

Chitosan (Deacetylated chitin)是一种高纯度生化试剂，适合作为生物材料或有机合成中间体，广泛应用于生命科学领域的研究与实验。

Chitosan (≥85% deacetylated, viscosity>90 mPa.s, MW 15000) (Deacetylated chitin (≥85% deacetylated, viscosity>90 mPa.s, MW 15000); Poly(D-glucosamine) (≥85% deacetylated, viscosity>90 mPa.s, MW 15000)) 是一种在生化反应中使用的试剂。

Chitosan (MW 150000) (Deacetylated chitin) 是衍生自几丁质的聚阳离子线性多糖。它无毒，具有低致敏性，生物相容性和可生物降解性。它还具有抗肿瘤，抗细菌，抗真菌和抗氧化活性。

Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性，或早发性心脏或中枢神经系统 (CNS) 毒性。

Gitoxigenin 是夹竹桃苷的脱乙酰同系物，是一种具有特定生物化学活性的天然产物。

HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.

HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng ml and human umbilical vein endothelial cells with an IC50value of 56.4 ng ml.1It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.3HT-2 toxin has been found in cereal grains and food products.4,5 1.Nielsen, C., Casteel, M., Didier, A., et al.Trichothecene-induced cytotoxicity on human cell linesMycotoxin Res.25(2)77-84(2009) 2.Nathanail, A.V., Varga, E., Meng-Reiterer, J., et al.Metabolism of the fusarium mycotoxins T-2 toxin and HT-2 toxin in wheatJ. Agric. Food Chem.63(35)7862-7872(2015) 3.Zhang, L., Li, L., Xu, J., et al.HT-2 toxin exposure induces mitochondria dysfunction and DNA damage during mouse early embryo developmentReprod. Toxicol.85104-109(2019) 4.Langseth, W., and Rundberget, T.The occurrence of HT-2 toxin and other trichothecenes in Norwegian cerealsMycopathologia147(3)157-165(1999) 5.Al-Taher, F., Cappozzo, J., Zweigenbaum, J., et al.Detection and quantitation of mycotoxins in infant cereals in the U.S. market by LC-MS MS using a stable isotope dilution assayFood Control72(Part A)27-35(2017)

1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants.

GSK1790627 是 Trametinib 的 N-脱乙酰代谢物。Trametinib 是一种具有口服活性的MEK 抑制剂，可激活自噬并诱导细胞凋亡。

Ganoderic acid T1是Ganoderic acid T的去乙酰化衍生物，具有促进癌细胞凋亡(apoptosis)的功能。它通过降低线粒体膜电位以及激活caspase-9和caspase-3来引发细胞凋亡，并增加细胞内ROS的产生，从而表现出促氧化活性和细胞性毒作用，同时减弱抗氧化防御系统。

Deacetylescin Ia (compound 12) 作为一种具有抗高血糖活性的脱乙酰基化合物,可以从经过去苦味处理的七叶树中提取,并在 C-22 位进行脱乙酰基化处理.在小鼠的糖耐量试验中,Deacetylescin Ia(100mg kg)显示出了抑制血糖升高的效果.