cross-resistance

Amcenestrant (SAR439859) 是一种有效的 ER 拮抗剂，具有 ER 降解活性，EC50为 0.2 nM。它是一种具有口服活性，非甾体和选择性雌激素受体降解剂 (SERD)。它可在 ER+乳腺癌中表现出强大的抗肿瘤功效和有限的交叉耐药性。

Broflanilide 是昆虫抗狄氏剂 GABA 受体拮抗剂，作用于昆虫 GABA 受体的全新变构位点，无交叉抗性，广谱高效。代谢物 Desmethyl-Broflanilide 可以抑制斜纹夜蛾 RDL GABAR，IC50 值为 1.3 nM。

Spirodiclofen (BAJ-2740) 是选择性非系统性的杀螨剂，来自新的化学类特酮酸衍生物， 与目前市面上的杀螨剂无交叉耐药, 具有额外的杀虫性能。

MBX-1162，一种双吲哚类化合物，研究显示，在金黄色葡萄球菌的耐药机制中，没有与其他相关化合物展现交叉耐药性，这与其对MepA和MepR的底物特异性相关。

Lenacapavir，又名GS-6207，是一种HIV-1 capsid抑制剂。其对23种来自不同亚型的HIV-1临床分离株表现出平均EC50为50 pM (20-160 pM)，这些测试是在周围血单核细胞（PBMCs）中进行的。Lenacapavir在体外显示出皮克摩尔级的有效性，且对现有抗逆转录病毒类化合物没有交叉抗性。此外，在HIV-1感染者中，Lenacapavir展现出强大的抗病毒活性，无论治疗历史如何，都没有发现对Lenacapavir的预存在抗性。

Trimelamol (CB10-375; NSC283162) 是一种高效的酸催化的DNA链间交联剂，具备有限的血脑屏障穿透性，从而导致较低的神经毒性。它表现出抗肿瘤活性并能够克服铂类耐药性。Trimelamol 被用于对肺癌和卵巢癌的研究。

Antiparasitic agent-29 (Compound 5) 是一种锥虫替代氧化酶 (TAO) 抑制剂，在 Trypanosoma brucei 中的 IC50 为 1.3 nM。这种化合物对锥氏虫和利什曼原虫属表现出广谱的抗寄生虫活性。它在寄生虫线粒体中积聚，选择性破坏其能量代谢，同时具备强大的膜扰动活性，并且不易产生交叉耐药性。Antiparasitic agent-29 可用于 surra 和 dourine 等寄生虫病的研究。

Picoplatin has a broad spectrum of antineoplastic activity and is designed to overcome platinum drug resistance. Picoplatin alkylates DNA, forming both intra- and inter-strand cross-linkages, resulting in the inhibition of DNA replication and transcriptio

WML-01 是一种杀菌剂，对 F. graminearum、F. fujikuroi 和 S. sclerotiorum 的 EC50 分别为 0.079 μg/mL、0.72 μg/mL 和 2.02 μg/mL。它能够破坏 F. graminearum 的细胞膜并诱导脂滴沉积。另外，WML-01 抑制脱氧雪腐镰刀菌烯醇 (DON) 的生物合成，无交叉抗性，并有效阻止核糖体亚基组装，从而损害蛋白质合成能力。WML-01 在控制小麦赤霉病 (FHB) 的流行方面表现卓越。

TRI-611是一种高选择性的ALK分子胶降解剂，能穿透血脑屏障，通过与CRBN E3连接酶结合，诱导ALK融合蛋白发生泛素化并被蛋白酶体降解。TRI-611能够高效降解包括TKI耐药突变体在内的多种EML4-ALK融合蛋白，并对ALK阳性非小细胞肺癌（Non-small cell lung cancer）模型表现出显著抗肿瘤活性。TRI-611可在皮下及颅内异种移植模型中诱导肿瘤退缩，且对ALK酪氨酸激酶抑制剂（TKIs）耐药模型同样有效，因此被用于ALK驱动肿瘤及耐药机制相关研究。

Lascufloxacin (KRP-AM-1977) is a potent antibacterial drug candidate. It exhibited the most potent activity against gram-positive bacteria among the quinolones tested. Lascufloxacin showed incomplete cross-resistance against existing quinolone-resistant s

Iproplatin(异丙铂)是一种与顺铂相关的含铂衍生物，能够与DNA结合并形成DNA交联及铂-DNA加合物，从而导致DNA复制失败和细胞死亡。与顺铂相比，Iproplatin对谷胱甘肽灭活的耐受性更佳。

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.

S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense and Trypanosoma vivax. Moreover, S-MGB-234 does not demonstrate cross-resistance with existing diamidine drugs and is not internalized through the transporters employed by diamidines.

Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts and disrupts the configuration of

Pyraziflumid is a fungicide. Pyraziflumid is a novel member of succinate dehydrogenase inhibitor fungicides (SDHI). The average EC50 value was 0.0561 (±0.0263)μg/ml for mycelial growth. There was no cross-resistance between pyraziflumid and the widely used fungicides carbendazim, dimethachlon and the phenylpyrrole fungicide fludioxonil.

Albizziin 是一种天冬酰胺合成酶的竞争性抑制剂，属于氨基酸类似物。Albizziin 可用于分离出目标酶水平变化的中国仓鼠卵巢细胞突变体。可以根据 Albizziin 突变体对β-天冬氨酸羟肟酸的交叉抗性，可将其区分为不同类别。

NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40 µM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication.

Ibrexafungerp citrate 是一种三萜类抗真菌药物，可抑制真菌细胞壁中 1,3-β-D-葡聚糖的合成。尽管其功能结果与棘白菌素类相似，但其结合于葡聚糖合酶的不同位点，从而具有有限的交叉耐药性。Ibrexafungerp citrate 对念珠菌属表现出浓度依赖性的杀真菌活性，并对多数氟康唑耐药菌株保持较强的体外活性，支持其在抗真菌耐药性和药物开发研究中的应用。

Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -be......

(6R)-ML753286 是 ML753286 的异构体。ML753286 是一种口服活性和选择性 BCRP(抗乳腺癌蛋白) 抑制剂，IC50为 0.6 μM。 ML753286 在啮齿动物和人类肝脏 S9 组分中具有高渗透性和低至中等清除率，并且在不同物种中都具有血浆稳定性。

Elastin, pig 是一种在细胞外基质中大量存在的基质蛋白，具有不溶性、无定形、广泛交联的特点，为器官和组织提供拉伸和回缩的能力，对除弹性蛋白酶外的多种蛋白酶具有抗性，常用作组织修复的生物材料。

Lividomycin B 是一种广谱氨基糖苷类抗生素，对细菌和分枝杆菌有效，与链霉菌及青霉菌之间无交叉耐药性，可保护感染金黄色葡萄球菌和铜绿假单胞菌的小鼠。

Pentaerythritol tetra(3-mercaptopropionate) 是一种含有季戊四醇和巯基丙酸酯基团的有机化合物。它在多种化学和工业领域中被用作稳定剂和交联剂。其特性包括增强聚合物与涂料的机械强度、热稳定性及耐候性。此外，它还可作为生产其他特种化学品和材料的原料。