topoisomerase ii inhibitor 13

Topoisomerase II inhibitor 13抑制拓扑异构酶II (Topo II)，对HL-60衍生的HL-60 MX2癌细胞具有较强的抗Topo II 毒性的抗增殖活性。

FLT3-IN-13 (compound 20) is a highly effective inhibitor targeting both topoisomerase II and FLT3 proteins in leukemic cells. It exhibits potent activity against these targets, with IC50 values of 2.26 μM for both. Moreover, FLT3-IN-13 induces cell cycle arrest at the G2 M phase and promotes apoptosis. Notably, it displays considerable anticytotoxic activity, specifically against leukemia [1].