sapropterin

Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatonin, norepinephrine, neurotransmitter

Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。

Tetrahydrobiopterin (BH4) 是芳香族氨基酸羟化酶的辅因子, 也是一氧化氮合酶 (NOS) 的必需辅因子，可用于研究如高血压、高胆固醇血症、糖尿病等内皮功能障碍。