PROTACTEAD degrader-1 (Compound 27) is a PROTAC degrader of the transcriptional enhanced associate domain (TEAD). It selectively degrades Flag TEAD2 through a ubiquitin-protease-dependent mechanism, with a DC50 of 54.1 nM in 293T cells. This compound inhibits the proliferation of NF2-deficient NCI-H226 cells, showing an IC50 of 0.21 μM, and modulates the expression of yes-associated protein (YAP) target genes.