Niraxostat

Name: Niraxostat
Brand: TargetMol
SKU: T33676
Price: 1090 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.13%

货号 T33676Cas号 206884-98-2

别名 Y-700, Y700, Y 700

Niraxostat (Y-700) 是作为黄嘌呤氧化酶抑制剂的异胞嘧啶衍生物之一。

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Niraxostat

一键复制产品信息

很棒

纯度: 98.13%

货号 T33676 别名 Y-700, Y700, Y 700Cas号 206884-98-2

Niraxostat (Y-700) 是作为黄嘌呤氧化酶抑制剂的异胞嘧啶衍生物之一。

规格	价格	库存
1 mg	¥ 1,090	现货
5 mg	¥ 2,230	现货
10 mg	¥ 3,260	现货
25 mg	¥ 5,220	现货
50 mg	¥ 7,160	现货
100 mg	¥ 9,660	现货
200 mg	¥ 12,800	现货
1 mL x 10 mM (in DMSO)	¥ 1,980	现货

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纯度: 98.13%

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COA HNMR LCMS 产品操作手册

产品介绍

Niraxostat AI Summary

Niraxostat exhibits significant bioactivity as a xanthine oxidase inhibitor, with an IC50 value of 5.8 nM. It shows potent inhibitory effects on bovine milk xanthine-oxygen reductase and reduces uric acid production remarkably, demonstrating a hypouricemic effect in potassium oxonate-treated rats with ED20 values of 0.55 mg·kg-1 and 1.4 mg·kg-1 at different time points. The compound demonstrates pharmacokinetic properties characterized by maximum plasma concentrations (Cmax) ranging from 467.71 nM to 21681.76 nM after oral administration and half-lives (T1/2) between 2.7 to 6.0 hours. It has a high degree of plasma protein binding at 97.76%. Niraxostat also exhibits bioactivities in cell proliferation assays against various cell lines, including HBL1, TMD8, and Plasmodium falciparum strains 3D7, DD2, and HB3, with potencies ranging from 18.8 nM to 26350.6 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Niraxostat (Y-700) is one of the isocytosine derivatives as xanthine oxidase inhibitors.
别名	Y-700, Y700, Y 700

化学信息

分子量	299.32
分子式	C₁₆H₁₇N₃O₃
CAS No.	206884-98-2
Smiles	C(#N)C=1C=C(C=CC1OCC(C)(C)C)N2C=C(C(O)=O)C=N2
密度	1.20 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (167.05 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3409 mL	16.7045 mL	33.4091 mL	167.0453 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL	33.4091 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL	16.7045 mL
20 mM	0.1670 mL	0.8352 mL	1.6705 mL	8.3523 mL
50 mM	0.0668 mL	0.3341 mL	0.6682 mL	3.3409 mL
100 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6705 mL