NESS 0327

Name: NESS 0327
Brand: TargetMol
SKU: T22114
Price: 987 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.78%

货号 T22114Cas号 494844-07-4

NESS 0327 是一种高选择性大麻素 CB1 受体拮抗剂。

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NESS 0327

一键复制产品信息

很棒

纯度: 99.78%

货号 T22114Cas号 494844-07-4

NESS 0327 是一种高选择性大麻素 CB1 受体拮抗剂。

规格	价格	库存
1 mg	¥ 987	现货
5 mg	¥ 2,460	现货
10 mg	¥ 3,590	现货
25 mg	¥ 5,770	现货
50 mg	¥ 7,780	现货
100 mg	¥ 10,500	现货

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产品介绍

NESS 0327 AI Summary

NESS 0327 demonstrates high affinity for the CB1 receptor with a Ki value of 0.00035 nM, indicating potent binding ability. In various assays, it also shows Ki values of 18.4 nM and 5.55 nM for displacing specific ligands from the CB1 receptor. The compound exhibits moderate binding affinity to the CB2 receptor with Ki values ranging from 20.0 nM to 21.0 nM. It displays a high selectivity for the CB1 receptor over the CB2 receptor, with a selectivity ratio of Ki values suggesting up to a 60,000-fold preference. Additionally, NESS 0327 acts as a CB1 receptor agonist with minimal activity at CB2 receptors. In functional assays using mouse N1E-115 cells, the compound demonstrates both antagonist activity by inhibiting WIN55,212-2-induced phosphorylation of ERK1/2 and intrinsic agonist activity by inducing phosphorylation of ERK1/2. The broad dataset supports its potential role in modulating cannabinoid receptor activity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.

化学信息

分子量	489.82
分子式	C₂₄H₂₃Cl₃N₄O
CAS No.	494844-07-4
Smiles	Clc1ccc(c(Cl)c1)-n1nc(C(=O)NN2CCCCC2)c2CCCc3cc(Cl)ccc3-c12
密度	1.474 g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: 0.25 mg/mL (0.51 mM), Sonication is recommended.