Name: N106
Brand: TargetMol
SKU: T28124
Price: 438 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 438

现货

5 mg

¥ 995

现货

10 mg

¥ 1,830

现货

25 mg

¥ 3,990

现货

50 mg

¥ 5,680

现货

100 mg

¥ 7,930

现货

1 mL x 10 mM (in DMSO)

¥ 1,180

现货

产品介绍

生物活性

产品描述	N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
体外活性	N106 (10 min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24 h in cardiomyocytes[1].
体内活性	N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10 mg/kg; i.v.) exhibits a half-life of 65.4 min and a Cmax of ∼2.24 μM[1].
别名	N-106, N 106

化学信息

分子量	354.38
分子式	C₁₇H₁₄N₄O₃S
CAS No.	862974-25-2
Smiles	COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
密度	1.390 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 56.7 mg/mL (160 mM), Sonication and heating to 60℃ are recommended.

溶液配制表

DMSO

体内实验配液计算器