n106

N106 是 SUMO 激活酶 E1 连接酶的激活剂，并触发 SERCA2a 的内在 sumoylation。 N106 可用于有关心力衰竭的研究。

EN106 是一种有效的 FEMIB 抑制剂，一种半胱氨酸反应性共价配体。EN106 破坏了对 FEM1B、FNIP1 的关键还原应力底物的识别。

GLN-1062 是 galantamine 的前体药物，在阿尔兹海默症中有研究价值。

SARS-CoV-2-IN-106 (compound 19) 为针对SARS-CoV-2类木瓜蛋白酶的抑制剂，其IC50值针对类木瓜蛋白酶为0.44 μM，针对病毒复制为0.18 μM。

EGFR-IN-106 (compound 6) 是一种有效的EGFR抑制剂，IC50值为 0.2396 µM，同时表现出显著的细胞毒性和抗炎活性。

Aclimostat (ZGN-1061) is a highly potent inhibitor of the MetAP2 enzyme that demonstrates promising efficacy and safety profiles in preclinical trials. In a mouse model of obesity and insulin resistance, ZGN-1061 exhibits comparable weight loss efficacy to beloranib, while also improving metabolic parameters. Additionally, ZGN-1061 induces consistent changes in gene transcription in HepG2 cells, further supporting its positive pharmacological effects.

Cefonicid (free base) is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

TX-1123是一种针对Src、eEF2-K、PKA和EGFR-K/PKC的有效蛋白酪氨酸激酶(PTK)抑制剂，同时也是一种环氧合酶(COX)抑制剂，对COX2和COX1的IC50值分别为1.16μM和15.7μM。它具有低线粒体毒性，可用于癌症研究。

MEN-10627 is a polycyclic peptide and tachykinin NK2 receptor antagonist.

MEN-10612 is a cyclic pseudopeptide and potent tachykinin NK-2 receptor antagonist.

WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.

香豆素 478 是乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）抑制剂，IC50分别为10.7和27.8µM。

Ganoderol A has significant anti-inflammatory activity and protection against UVA damage. it has an inhibitory effect on angiotensin converting enzyme activity and cholesterol biosynthesis.

Ganoderol B是一种发现于Ganoderma lucidum的天然产物和α-glucosidase抑制剂，IC50=119.8 μM，可用于研究糖尿病。

Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast cancer cells.

Imidazoleacetic acid riboside 是一种组胺代谢物，存在于大鼠组织中。这种咪唑类核糖核糖体可能在生物体的生长、发育或繁殖研究中具有应用潜力。

Calycanthine是一种天然的生物碱，具有中枢神经系统毒性，可引起抽搐和惊厥。

Aristolochic acid C 是马兜铃酸的一种衍生物，是磷脂酶 A 抑制剂。Aristolochic acid C 作用于拟南芥，可破坏间期细胞的周质微管列阵和抑制根生长。

Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。

Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 μM, it may have anti-influenza virus activity.

Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) 是 NF-κB 抑制剂，同时也是 DNA 裂解抑制剂。

Tricin 是米糠中大量存在的一种天然类黄酮。它通过抑制 CDK9 来抑制HCMV 的复制。它通过上调 FAK 靶向 microRNA-7 的表达来抑制 C6 胶质瘤细胞的增殖和侵袭。

Prion peptide fragment that exhibits neurotoxicity