Ethotoin (oral gavage; 600 mg/kg; once) causes mild mortality and weight loss of offspring, after dosing on gestational day 18 [2]. Animal Model: Pregnant Sprague-Dawley CD rats [2] Dosage: 600 mg/kg Administration: Oral gavage; 600 mg/kg; once Result: Preweaning mortality for Ethotoin was 2.0%, Ethotoin -exposed animals weighed approximately 6.6% less than controls.