store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063.
产品描述 | DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with IC50 value of 0.0063. |
靶点活性 | MTHFD2:0.0063 μM , MTHFD1:0.57 μM |
体外活性 | DS18561882 (0-150 nM) gives the lowest GI50 value (140 nM) against the MDA-MB-231 cell line. |
体内活性 | DS18561882 (oral;10mg /kg, 30mg /kg, 100mg /kg or 300mg /kg) had good oral drug kinetics, including ACU(64.6, 264, 726ug. H /ml).;Cmax (11.4, 56.5, 90.1 ° g/ml).T1/2 (2.21, 2.16, 2.32 hours) at 30 mg/kg;100 mg/kg;200 mg/kg, respectively.DS18561882 was suspended in 0.5% (W/V) methyl cellulose 400 solution.DS18561882 (oral;30, 100 or 300 mg/kg;Tumor growth inhibition was inhibited in a dose-dependent manner and was completely inhibited in mice at a dose of 300 mg/kg (TGI: 67%). |
分子量 | 608.63 |
分子式 | C28H31F3N4O6S |
CAS No. | 2227149-22-4 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (410.76 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.643 mL | 8.2152 mL | 16.4303 mL | 41.0759 mL |
5 mM | 0.3286 mL | 1.643 mL | 3.2861 mL | 8.2152 mL | |
10 mM | 0.1643 mL | 0.8215 mL | 1.643 mL | 4.1076 mL | |
20 mM | 0.0822 mL | 0.4108 mL | 0.8215 mL | 2.0538 mL | |
50 mM | 0.0329 mL | 0.1643 mL | 0.3286 mL | 0.8215 mL | |
100 mM | 0.0164 mL | 0.0822 mL | 0.1643 mL | 0.4108 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DS18561882 2227149-22-4 Others DS-18561882 DS 18561882 Inhibitor inhibitor inhibit