Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-BDBD 是选择性P2X4受体拮抗剂,抑制 rP2X4R 介导的电流,IC50为0.75μM。它可完全阻断硝酸甘油诱导的基础性和急性痛觉过敏。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 347 | 现货 | ||
2 mg | ¥ 497 | 现货 | ||
5 mg | ¥ 829 | 现货 | ||
10 mg | ¥ 1,430 | 现货 | ||
25 mg | ¥ 3,160 | 现货 | ||
50 mg | ¥ 4,630 | 现货 | ||
100 mg | ¥ 6,580 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 897 | 现货 |
产品描述 | 5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG. |
靶点活性 | P2X4:0.75 μM |
体外活性 | 5-BDBD could be specifically used to discriminate between P2X1R, P2X2aR, P2X2bR, P2X3R, P2X4R, and P2X7R[1]. 5-BDBD inhibits 10 μM ATP-induced currents of rP2X4R-expressing HEK293 cells in a concentration-dependent manner, with an IC50 of 0.75 μM[1]. 5-BDBD displaces rightward the ATP concentration-response curve, with an EC50 of 4.7 to 15.9 μM[1]. |
体内活性 | Basal hyperalgesia induced by recurrent NTG injection was completely blocked by 5-BDBD[2]. |
动物实验 | 5-BDBD (28 mg/kg; i.p.; daily for 9 days; male C57BL/6 mice) prevented NTG-induced mechanical hypersensitivity[2]. |
分子量 | 355.19 |
分子式 | C17H11BrN2O2 |
CAS No. | 768404-03-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (168.92 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8154 mL | 14.077 mL | 28.1539 mL | 70.3849 mL |
5 mM | 0.5631 mL | 2.8154 mL | 5.6308 mL | 14.077 mL | |
10 mM | 0.2815 mL | 1.4077 mL | 2.8154 mL | 7.0385 mL | |
20 mM | 0.1408 mL | 0.7038 mL | 1.4077 mL | 3.5192 mL | |
50 mM | 0.0563 mL | 0.2815 mL | 0.5631 mL | 1.4077 mL | |
100 mM | 0.0282 mL | 0.1408 mL | 0.2815 mL | 0.7038 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
5-BDBD 768404-03-1 Membrane transporter/Ion channel Neuroscience P2X Receptor inhibit P2XRs currents NTG hyperalgesia selective Inhibitor ATP 5BDBD acute 5 BDBD inhibitor