Powder: -20°C for 3 years | In solvent: -80°C for 2 years
5-Aminolevulinic acid hydrochloride 是体内血红素生物合成的中间体,也是四吡咯的通用前体。
产品描述 | Aminolevulinic acid hydrochloride is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. | ||||||||||||||||
体外活性 |
5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumors. Median follow-up was 35.4 months (95% CI 1.0-56.7). A contrast-enhancing tumor was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (the difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression-free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2].
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别名 | 5-Aminolevulinic acid HCl, 氨基酮戊酸, Hydrangin, ALA hydrochloride, 5-ALA, 5-氨基乙酰丙酸盐酸盐 |
分子量 | 167.59 |
分子式 | C5H10ClNO3 |
CAS No. | 5451-09-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
H2O: 31 mg/mL (185 mM)
Ethanol: 6 mg/mL (35.8 mM)
DMSO: 32 mg/mL (190.9 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
5-Aminolevulinic acid hydrochloride 5451-09-2 Apoptosis Autophagy Metabolism Mitophagy Endogenous Metabolite 5-Aminolevulinic acid HCl 氨基酮戊酸 δ-Aminolevulinic acid inhibit 5Aminolevulinic acid hydrochloride Hydrangin ALA hydrochloride 5-ALA Inhibitor 5 Aminolevulinic acid hydrochloride 5-氨基乙酰丙酸盐酸盐 5-Aminolevulinic acid Mitochondrial Autophagy inhibitor