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1-Oleoyl Lysophosphatidic Acid

1-Oleoyl Lysophosphatidic Acid

产品编号 T36907   CAS 65528-98-5
别名: Oleoyl-sn-3-Glycerophosphate, 1-Oleoyl LPA, 1-Oleoyl Lysophosphatidic Acid

1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.[2],[1] 1-Oleoyl lysophosphatidic acid is the most potent of the LPA analogs for calcium mobilization in A431 cells and for growth stimulation of a variety of cell lines.[3],[4] 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 1-Oleoyl lysophosphatidic acid sodium 的水溶性和稳定性通常比游离态更好。

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1-Oleoyl Lysophosphatidic Acid Chemical Structure
1-Oleoyl Lysophosphatidic Acid, CAS 65528-98-5
规格 价格/CNY 货期 数量
1 mg ¥ 455 35日内发货
5 mg ¥ 1,780 35日内发货
10 mg ¥ 2,920 35日内发货
25 mg ¥ 6,140 35日内发货

1-Oleoyl Lysophosphatidic Acid 的其他形式现货产品:

1-Oleoyl lysophosphatidic acid sodium
其他形式的 1-Oleoyl Lysophosphatidic Acid:
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BCA蛋白浓度测定试剂盒限时半价
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产品目录号及名称: 1-Oleoyl Lysophosphatidic Acid (T36907)
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生物活性
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参考文献
产品描述 1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.[2],[1] 1-Oleoyl lysophosphatidic acid is the most potent of the LPA analogs for calcium mobilization in A431 cells and for growth stimulation of a variety of cell lines.[3],[4]
别名 Oleoyl-sn-3-Glycerophosphate, 1-Oleoyl LPA, 1-Oleoyl Lysophosphatidic Acid
分子量 436.526
分子式 C21H41O7P
CAS No. 65528-98-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 25 mg/mL

DMF: 2 mg/mL

DMSO: 2.5 mg/mL

PBS (pH 7.2): 3 mg/mL

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TargetMol Library Books参考文献

1. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions. Trends in Cell Biology 4, 213-219 (1994). 2. Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. The Journal of Biological Chemisty 278(28), 25600-25606 (2003). 3. Jalink, K., Hengeveld, T., Mulder, S., et al. Lysophosphatidic acid-induced Ca2+ mobilization in human A4431 cells: Structure-activity analysis. Biochemistry Journal 307, 609-616 (1995). 4. van Corven, E.J., van Rijswijk, A., Jalink, K., et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochemistry Journal 281, 163-169 (1992).

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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

1-Oleoyl Lysophosphatidic Acid 65528-98-5 1 Oleoyl Lysophosphatidic Acid Oleoyl-sn-3-Glycerophosphate 1Oleoyl Lysophosphatidic Acid 1-Oleoyl LPA Inhibitor inhibitor inhibit

 

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