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1,4-Naphthoquinone

Name: 1,4-Naphthoquinone
Brand: TargetMol
SKU: T7048
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.56%

货号 T7048Cas号 130-15-4

别名 α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione, 1,4-萘醌

1,4-Naphthoquinone (P-Naphthoquinone) 被用作单胺氧化酶和 DNA 拓扑异构酶活性的潜在抑制剂，还用于抑制乙酰转移酶活性。

1,4-Naphthoquinone

一键复制产品信息

很棒

纯度: 99.56%

货号 T7048 别名 α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione, 1,4-萘醌Cas号 130-15-4

1,4-Naphthoquinone (P-Naphthoquinone) 被用作单胺氧化酶和 DNA 拓扑异构酶活性的潜在抑制剂，还用于抑制乙酰转移酶活性。

规格	价格	库存	数量
100 g	¥ 129	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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实验操作小课堂

常见问题解答

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纯度: 99.56%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

1,4-Naphthoquinone AI Summary

1,4-Naphthoquinone exhibits a variety of bioactivities and inhibitory effects across multiple biological targets. It inhibits topoisomerase I with a minimal inhibitory concentration (MIC) greater than 500,000.0 nM and topoisomerase 2 ATPase domain with a 56% inhibition rate at 25 μM. It effectively increases survival time in mice against ascitic sarcoma 180, showing an ED25 of 1.9 mg/kg, and exhibits acute toxicity with an LD50 of 5.5 mg/kg. The compound demonstrates significant vasorelaxation, inhibiting acetylcholine-induced relaxation in rat aorta with an EC50 of 127.0 nM and an Emax of 98.0%. Furthermore, it shows protease inhibitory activity with IC50 values of 21,000.0 nM and 29,000.0 nM against HRV 3Cpro and papain, respectively, as well as 76.0% inhibition against papain. It has notable antiproliferative and cytotoxic effects against various cancer cell lines including murine leukemia, human lung carcinoma, colon carcinoma, melanoma, A2780, MG63, HepG2, MCF7, HT-29, MDA-MB-231, DU145, HCT116, SKOV3, and A549, with IC50 values ranging from 2,300.0 nM to greater than 25,000.0 nM depending on the cell line. 1,4-Naphthoquinone exhibits antimycobacterial activity, with a MIC of 1.0 μg/mL against Mycobacterium tuberculosis H37Rv and an IC50 of 1.2 μg/mL for cytotoxicity against Vero cells. It inhibits IDO1 (IC50 = 460.0 nM), MEK1 (IC50 = 380.0 nM), histone methyltransferases GLP (IC50 = 14,000.0 nM) and G9a (IC50 = 2,000.0 nM), recombinant Clostridium botulinum neurotoxin serotype A, recombinant AKT1, human recombinant MAO-A and MAO-B, and the human recombinant Pin1 enzyme. Additionally, the compound exhibits binding and inhibition of Mycobacterium tuberculosis Rv1284 (76.6% activity reduction at 25 μM) and N-terminal Hi-tagged Rv3588c (94.8% activity reduction at 25 μM). It demonstrates neuroprotective properties in mouse HT22 cells, with a therapeutic index (TI) of 12.0 and exhibits glutathione reactivity (20.0% to 47.0%). Finally, 1,4-Naphthoquinone inhibits SARS-CoV-2 main protease with an IC50 of 129.77 nM, and has antiviral activity against SARS-CoV-2 in Vero-6 cells with IC50 values greater than 20,000.0 nM. These diverse bioactivities and inhibitory effects make 1,4-Naphthoquinone a multifaceted candidate for further pharmacological and therapeutic evaluations..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].
别名	α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione, 1,4-萘醌

化学信息

分子量	158.15
分子式	C₁₀H₆O₂
CAS No.	130-15-4
Smiles	O=C1C=CC(=O)C2=C1C=CC=C2
密度	1.42

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (284.54 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3231 mL	31.6156 mL	63.2311 mL	316.1555 mL
5 mM	1.2646 mL	6.3231 mL	12.6462 mL	63.2311 mL
10 mM	0.6323 mL	3.1616 mL	6.3231 mL	31.6156 mL
20 mM	0.3162 mL	1.5808 mL	3.1616 mL	15.8078 mL
50 mM	0.1265 mL	0.6323 mL	1.2646 mL	6.3231 mL
100 mM	0.0632 mL	0.3162 mL	0.6323 mL	3.1616 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

topoisomerase Topo oxidase naphthoquinone monoamine MAO Inhibitor inhibit a-Naphthoquinone alpha-Naphthoquinone acetyltransferase 1,4-Naphthoquinone 1,4Naphthoquinone 1,4 Naphthoquinone

1,4-Naphthoquinone

1,4-Naphthoquinone