Trk receptor

Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. Trk receptors affect neuronal survival and differentiation through several signaling cascades.The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor. The activation of Trk receptors by neurotrophin binding may lead to activation of signal cascades resulting in promoting survival and other functional regulation of cells.

Cat. No.	Product Name	CAS No.	Purity
T78968	TRK-IN-23 化合物 TRK-IN-23	2924344-29-4	98%
T78968	TRK-IN-23 (compound 24b) 是一款口服活性TRK抑制剂，对TRKA、TRKC、TRKAG595R、TRKAF589L和TRKAG667C 表现出高效的抑制作用，其IC50值分别为0.5 nM、9 nM、14 nM、4.4 nM和4.8 nM。此外，TRK-IN-23 能够诱导含有TRKAG595R和...
T79011	TrkB-IN-1 化合物 TrkB-IN-1	1609067-49-3	98%
T79011	TrkB-IN-1为一种有效的口服活性TrkB激动剂，展现出优良的药代动力学特性。该化合物能够逆转AD模型小鼠的认知功能缺陷，适用于阿尔茨海默病的研究。
T79125	Protein kinase inhibitor 5 化合物 Protein kinase inhibitor 5	2278204-94-5	98%
T79125	Protein kinase inhibitor 5 作为一种有效的TRK-A抑制剂，其IC50值达到1.8 nM，且能抑制细胞活力。
T79126	Protein kinase inhibitor 5 sulfate hydrate 化合物 Protein kinase inhibitor 5 sulfate hydrate		98%
T79126	Protein kinase inhibitor 5 sulfate hydrate 作为TRK-A抑制剂，具有高效性，其IC50值仅为1.8 nM，能有效抑制细胞活力。
T79706	TRK-IN-24 化合物 TRK-IN-24	2937544-01-7	98%
T79706	TRK-IN-24（compound 10g）是一种针对Trk Receptor的抑制剂，它对TRKA、TRKC、TRKAG595R、TRKAG667C和TRKAF589L的抑制作用的IC50值分别达到5.21、4.51、6.77、1.42和6.13 nM。该化合物在BaF3-CD74-NTRK1G595R和BaF3-C...
T81740	Multi-kinase-IN-6 化合物 Multi-kinase-IN-6		98%
T81740	Multi-kinase-IN-6 (compound 10e) 是一种效能极高的多激酶抑制剂，具有对 TrkA、ALK2、c-KIT、EGFR、PIM1、CK2α、CHK1 和 CDK2 等多种酶的显著抑制作用。在 MCF7、HCT116 和 EKVX 癌细胞系上，其抗增殖活性突出，IC50 值分别达到 3.36 μM...
T13208	TrkA-IN-1 化合物 T13208	1680179-43-4	98%
T13208	TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.
T6936	PF-03814735 化合物PF-03814735	942487-16-3	98%
T6936	PF-03814735 是一种新型、有效和可逆的极光激酶 A 和 B 抑制剂，IC50值分别为0.8和5 nM。
T13207	PF-06733804 化合物 T13207	1873373-33-1	98%
T13207	PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
TN2890	3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one 化合物 TN2890	244277-75-6	98%
TN2890	3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one是一种天然产物，属于大戟科大戟属，其产品编号为 TN2890，CAS号为 244277-75-6。3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11...
T17000	Tavilermide 化合物 T17000	263251-78-1	98%
T17000	Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic.
T72289	Type II TRK inhibitor 1 化合物 Type II TRK inhibitor 1	2937543-72-9	98%
T72289	Type II TRK inhibitor 1 是有效抑制多种TRK融合蛋白及野生型的TRK抑制剂。对携有CD74-TRKAG667C及ETV6-TRKCG696C融合蛋白的Ba/F3细胞表现出抗增殖活性，其IC50值分别为6 nM与1.7 nM。
T73033	TRK II-IN-1 化合物 TRK II-IN-1	2904690-41-9	98%
T73033	TRKII-IN-1 是一种有效的 II 型TRK抑制剂，对TRKA/B/C及TRKAG667C的IC50分别为3.3、6.4、4.3 和 9.4 nM。此外，TRKII-IN-1 对FLT3、RET和VEGFR2也具有抑制作用，其IC50分别为1.3、9.9 和 71.1 nM。TRKII-IN-1 主要用于TRK驱动...
T17170	PF-06737007 化合物 T17170	1863905-38-7	98%
T17170	PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).
T17169	Trk-IN-4 化合物 T17169	1799788-94-5	98%
T17169	Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
T22318	Taletrectinib 化合物DS-6051b	1505515-69-4	99.96%
T22318	Taletrectinib (AB-106) 是具有口服活力的、选择性的 ROS1/NTRK 抑制剂。它对重组 ROS1、NTRK1、NTRK2 和 NTRK3 有较强的抑制作用，IC50值分别为 0.207、0.622、2.28 和 0.98 nM。它还抑制 ROS1 G2032R 和其他抗 Crizotinib 的 ...
T2359	ANA-12 化合物ANA-12	219766-25-3	99.87%
T2359	ANA-12 是一种选择性TrkB 拮抗剂，对高亲和力和低亲和力位点的IC50分别为45.6 nM 和41.1 μM。
T4071	Repotrectinib 化合物TPX0005	1802220-02-5	99.86%
T4071	Repotrectinib (TPX-0005) 是ROS1(IC50=0.07 nM) 和TRK(对 TRKA/B/C 的IC50=0.83/0.05/0.1 nM) 抑制剂，能够抑制 WTALK(IC50=1.01 nM)。它具有抗癌作用。
T6081	Milciclib 化合物Milciclib	802539-81-7	99.73%
T6081	Milciclib (PHA-848125) 是一种 ATP 竞争性的 CDK 和原肌球蛋白受体激酶双重抑制剂，作用于 CDK2，IC50 为 45 nM。
T3678	Entrectinib 恩曲替尼	1108743-60-7	99.61%
T3678	Entrectinib (RXDX-101) 是一种可口服的 Trk、ROS1和 ALK 抑制剂，具有抗肿瘤和中枢神经活性，抑制 TrkA、TrkB、TrkC、ROS1 和 ALK 的 IC50值分别为 1、3、5、12 和 7 nM。