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Trk receptor

Trk receptor

Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. Trk receptors affect neuronal survival and differentiation through several signaling cascades.The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor. The activation of Trk receptors by neurotrophin binding may lead to activation of signal cascades resulting in promoting survival and other functional regulation of cells.
TargetMol
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Cat. No. Product Name CAS No. Purity Chemical Structure
T78968 TRK-IN-23
化合物 TRK-IN-23
2924344-29-4 98%
TargetMol Chemical Structure TRK-IN-23
TRK-IN-23 (compound 24b) 是一款口服活性TRK抑制剂,对TRKA、TRKC、TRKAG595R、TRKAF589L和TRKAG667C 表现出高效的抑制作用,其IC50值分别为0.5 nM、9 nM、14 nM、4.4 nM和4.8 nM。此外,TRK-IN-23 能够诱导含有TRKAG595R和...
T79011 TrkB-IN-1
化合物 TrkB-IN-1
1609067-49-3 98%
TargetMol Chemical Structure TrkB-IN-1
TrkB-IN-1为一种有效的口服活性TrkB激动剂,展现出优良的药代动力学特性。该化合物能够逆转AD模型小鼠的认知功能缺陷,适用于阿尔茨海默病的研究。
T79125 Protein kinase inhibitor 5
化合物 Protein kinase inhibitor 5
2278204-94-5 98%
TargetMol Chemical Structure Protein kinase inhibitor 5
Protein kinase inhibitor 5 作为一种有效的TRK-A抑制剂,其IC50值达到1.8 nM,且能抑制细胞活力。
T79126 Protein kinase inhibitor 5 sulfate hydrate
化合物 Protein kinase inhibitor 5 sulfate hydrate
98%
TargetMol Chemical Structure Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate 作为TRK-A抑制剂,具有高效性,其IC50值仅为1.8 nM,能有效抑制细胞活力。
T79706 TRK-IN-24
化合物 TRK-IN-24
2937544-01-7 98%
TargetMol Chemical Structure TRK-IN-24
TRK-IN-24(compound 10g)是一种针对Trk Receptor的抑制剂,它对TRKA、TRKC、TRKAG595R、TRKAG667C和TRKAF589L的抑制作用的IC50值分别达到5.21、4.51、6.77、1.42和6.13 nM。该化合物在BaF3-CD74-NTRK1G595R和BaF3-C...
T81740 Multi-kinase-IN-6
化合物 Multi-kinase-IN-6
98%
TargetMol Chemical Structure Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) 是一种效能极高的多激酶抑制剂,具有对 TrkA、ALK2、c-KIT、EGFR、PIM1、CK2α、CHK1 和 CDK2 等多种酶的显著抑制作用。在 MCF7、HCT116 和 EKVX 癌细胞系上,其抗增殖活性突出,IC50 值分别达到 3.36 μM...
T13208 TrkA-IN-1
化合物 T13208
1680179-43-4 98%
TargetMol Chemical Structure TrkA-IN-1
TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.
T6936 PF-03814735
化合物PF-03814735
942487-16-3 98%
TargetMol Chemical Structure PF-03814735
PF-03814735 是一种新型、有效和可逆的极光激酶 A 和 B 抑制剂,IC50值分别为0.8和5 nM。
T13207 PF-06733804
化合物 T13207
1873373-33-1 98%
TargetMol Chemical Structure PF-06733804
PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
TN2890 3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one
化合物 TN2890
244277-75-6 98%
TargetMol Chemical Structure 3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one是一种天然产物,属于大戟科大戟属,其产品编号为 TN2890,CAS号为 244277-75-6。3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11...
T17000 Tavilermide
化合物 T17000
263251-78-1 98%
TargetMol Chemical Structure Tavilermide
Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic.
T72289 Type II TRK inhibitor 1
化合物 Type II TRK inhibitor 1
2937543-72-9 98%
TargetMol Chemical Structure Type II TRK inhibitor 1
Type II TRK inhibitor 1 是有效抑制多种TRK融合蛋白及野生型的TRK抑制剂。对携有CD74-TRKAG667C及ETV6-TRKCG696C融合蛋白的Ba/F3细胞表现出抗增殖活性,其IC50值分别为6 nM与1.7 nM。
T73033 TRK II-IN-1
化合物 TRK II-IN-1
2904690-41-9 98%
TargetMol Chemical Structure TRK II-IN-1
TRKII-IN-1 是一种有效的 II 型TRK抑制剂,对TRKA/B/C及TRKAG667C的IC50分别为3.3、6.4、4.3 和 9.4 nM。此外,TRKII-IN-1 对FLT3、RET和VEGFR2也具有抑制作用,其IC50分别为1.3、9.9 和 71.1 nM。TRKII-IN-1 主要用于TRK驱动...
T17170 PF-06737007
化合物 T17170
1863905-38-7 98%
TargetMol Chemical Structure PF-06737007
PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).
T17169 Trk-IN-4
化合物 T17169
1799788-94-5 98%
TargetMol Chemical Structure Trk-IN-4
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
T62447 Paltimatrectinib
化合物 Paltimatrectinib
2353522-15-1 99.96%
TargetMol Chemical Structure Paltimatrectinib
Paltimatrectinib (PBI-200) 是一种高效的酪氨酸激酶 (tyrosine kinase) 抑制剂,具有抗癌活性,抑制肌球蛋白相关激酶 A (TrkA) 。Paltimatrectinib 可用于研究膀胱癌、乳腺癌和结直肠癌。
T22318 Taletrectinib
化合物DS-6051b
1505515-69-4 99.96%
TargetMol Chemical Structure Taletrectinib
Taletrectinib (AB-106) 是具有口服活力的、选择性的 ROS1/NTRK 抑制剂。它对重组 ROS1、NTRK1、NTRK2 和 NTRK3 有较强的抑制作用,IC50值分别为 0.207、0.622、2.28 和 0.98 nM。它还抑制 ROS1 G2032R 和其他抗 Crizotinib 的 ...
T1354 N-Acetyl-5-hydroxytryptamine
N-乙酰-5-羟色胺
1210-83-9 99.91%
TargetMol Chemical Structure N-Acetyl-5-hydroxytryptamine
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体,能够有效激活TrkB 受体。
T0678 Amitriptyline hydrochloride
盐酸阿米替林
549-18-8 99.87%
TargetMol Chemical Structure Amitriptyline hydrochloride
Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂,还与多巴胺再摄取转运体结合,其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂,具有强神经营养活性和有抗抑郁作...
T4071 Repotrectinib
化合物TPX0005
1802220-02-5 99.86%
TargetMol Chemical Structure Repotrectinib
Repotrectinib (TPX-0005) 是ROS1(IC50=0.07 nM) 和TRK(对 TRKA/B/C 的IC50=0.83/0.05/0.1 nM) 抑制剂,能够抑制 WTALK(IC50=1.01 nM)。它具有抗癌作用。
TRK-IN-23
T78968
TRK-IN-23 (compound 24b) 是一款口服活性TRK抑制剂,对TRKA、TRKC、TRKAG595R、TRKAF589L和TRKAG667C 表现出高效的抑制作用,其IC50值分别为0.5 nM、9 nM、14 nM、4.4 nM和4.8 nM。此外,TRK-IN-23 能够诱导含有TRKAG595R和...
TrkB-IN-1
T79011
TrkB-IN-1为一种有效的口服活性TrkB激动剂,展现出优良的药代动力学特性。该化合物能够逆转AD模型小鼠的认知功能缺陷,适用于阿尔茨海默病的研究。
Protein kinase inhibitor 5
T79125
Protein kinase inhibitor 5 作为一种有效的TRK-A抑制剂,其IC50值达到1.8 nM,且能抑制细胞活力。
Protein kinase inhibitor 5 sulfate hydrate
T79126
Protein kinase inhibitor 5 sulfate hydrate 作为TRK-A抑制剂,具有高效性,其IC50值仅为1.8 nM,能有效抑制细胞活力。
TRK-IN-24
T79706
TRK-IN-24(compound 10g)是一种针对Trk Receptor的抑制剂,它对TRKA、TRKC、TRKAG595R、TRKAG667C和TRKAF589L的抑制作用的IC50值分别达到5.21、4.51、6.77、1.42和6.13 nM。该化合物在BaF3-CD74-NTRK1G595R和BaF3-C...
Multi-kinase-IN-6
T81740
Multi-kinase-IN-6 (compound 10e) 是一种效能极高的多激酶抑制剂,具有对 TrkA、ALK2、c-KIT、EGFR、PIM1、CK2α、CHK1 和 CDK2 等多种酶的显著抑制作用。在 MCF7、HCT116 和 EKVX 癌细胞系上,其抗增殖活性突出,IC50 值分别达到 3.36 μM...
TrkA-IN-1
T13208
TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.
PF-03814735
T6936
PF-03814735 是一种新型、有效和可逆的极光激酶 A 和 B 抑制剂,IC50值分别为0.8和5 nM。
PF-06733804
T13207
PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one
TN2890
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one是一种天然产物,属于大戟科大戟属,其产品编号为 TN2890,CAS号为 244277-75-6。3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11...
Tavilermide
T17000
Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic.
Type II TRK inhibitor 1
T72289
Type II TRK inhibitor 1 是有效抑制多种TRK融合蛋白及野生型的TRK抑制剂。对携有CD74-TRKAG667C及ETV6-TRKCG696C融合蛋白的Ba/F3细胞表现出抗增殖活性,其IC50值分别为6 nM与1.7 nM。
TRK II-IN-1
T73033
TRKII-IN-1 是一种有效的 II 型TRK抑制剂,对TRKA/B/C及TRKAG667C的IC50分别为3.3、6.4、4.3 和 9.4 nM。此外,TRKII-IN-1 对FLT3、RET和VEGFR2也具有抑制作用,其IC50分别为1.3、9.9 和 71.1 nM。TRKII-IN-1 主要用于TRK驱动...
PF-06737007
T17170
PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).
Trk-IN-4
T17169
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
Paltimatrectinib
T62447
Paltimatrectinib (PBI-200) 是一种高效的酪氨酸激酶 (tyrosine kinase) 抑制剂,具有抗癌活性,抑制肌球蛋白相关激酶 A (TrkA) 。Paltimatrectinib 可用于研究膀胱癌、乳腺癌和结直肠癌。
Taletrectinib
T22318
Taletrectinib (AB-106) 是具有口服活力的、选择性的 ROS1/NTRK 抑制剂。它对重组 ROS1、NTRK1、NTRK2 和 NTRK3 有较强的抑制作用,IC50值分别为 0.207、0.622、2.28 和 0.98 nM。它还抑制 ROS1 G2032R 和其他抗 Crizotinib 的 ...
N-Acetyl-5-hydroxytryptamine
T1354
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体,能够有效激活TrkB 受体。
Amitriptyline hydrochloride
T0678
Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂,还与多巴胺再摄取转运体结合,其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂,具有强神经营养活性和有抗抑郁作...
Repotrectinib
T4071
Repotrectinib (TPX-0005) 是ROS1(IC50=0.07 nM) 和TRK(对 TRKA/B/C 的IC50=0.83/0.05/0.1 nM) 抑制剂,能够抑制 WTALK(IC50=1.01 nM)。它具有抗癌作用。
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