Name: Anti-NGF/bNGF Antibody
Brand: TargetMol
SKU: T9901A-1411
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-NGF/bNGF Antibody is a humanized monoclonal antibody that binds specifically to β-NGF (bNGF) with high affinity, blocking its interaction with TrkA and p75NTR receptors and inhibiting downstream signaling. It serves as an important pharmacological tool for researching chronic pain, inflammatory pain, and neurogenic inflammation.
体外活性	在生化实验中，Anti-NGF/bNGF Antibody表现出对重组人 β-NGF 的高结合亲和力，并能有效中和 PC12 细胞中由 NGF 诱导的突触生长 [1]。
体内活性	在利用骨关节炎和癌症诱发骨痛的小鼠或大鼠模型进行的药理学研究中，系统给予Anti-NGF/bNGF Antibody导致痛相关行为和超敏反应显著且呈剂量依赖性降低，且不影响正常的感官或运动功能，证实了其在调节外周敏化方面的功效 [1][2]。
别名	抗NGF/bNGF抗体, AS2886401-00
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG2SA

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P01138
靶点	NGF/bNGF

储存&溶解度

存储

Anti-NGF/bNGF Antibody