SGLT

Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. Glucose is never secreted by a healthy nephron.

Cat. No.	Product Name	CAS No.	Purity
T12893	SGLT inhibitor-1 化合物 T12893	2247314-23-2	98%
T12893	SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).
T12892	SGL5213 化合物 T12892	1240305-17-2	98%
T12892	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM ...
T15752	Licogliflozin 化合物Licogliflozin	1291094-73-9	98%
T15752	Licogliflozin (LIK066) 是钠-葡萄糖协同转运蛋白 (SGLT1和SGLT2) 的有效抑制剂。
TN4784	Picraline 化合物 TN4784	2671-32-1	98%
TN4784	A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.
T15807	LY2794193 化合物 T15807	2173037-97-1	98%
T15807	LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).
T11671	IRAK inhibitor 4 trans 化合物 T11671	T11671	98%
T11671	IRAK inhibitor 4 is a compound that functions as an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It specifically targets and inhibits the act...
T15505	HSK0935 化合物 T15505	1638851-44-1	98%
T15505	HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
TN4399	Kushenol C 化合物 TN4399	99119-73-0	98%
TN4399	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T17221	Velagliflozin 化合物 T17221	946525-65-1	98%
T17221	Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.
T2385	Ipragliflozin 伊格列净	761423-87-4	99.97%
T2385	Ipragliflozin (ASP1941) 是一种口服有效的，选择性的 SGLT2抑制剂，对人 SGLT2 和 SGLT1，大鼠 SGLT2 和 SGLT1，小鼠 SGLT2 和 SGLT1 的 IC50分别为 7.38 和 1876 nM，6.73 和 1166 nM，5.64 和 1380 nM。Ipraglif...
T1782L	Canagliflozin hemihydrate 卡格列净半水合物	928672-86-0	99.96%
T1782L	Canagliflozin hemihydrate (TA 7284) (JNJ28431754 hemihydrate) 是一种选择性的 SGLT2 抑制剂，作用于表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO 细胞，IC50 分别为 2 nM，3.7 nM 和 4.4 nM。
T1766	Empagliflozin 恩格列净	864070-44-0	99.89%
T1766	Empagliflozin (BI 10773) 是一种 SGLT-2 抑制剂 (IC50=3.1 nM)，具有有效的和选择性，对 SGLT-1/4/5/6 的选择性高 300 倍以上。Empagliflozin 可用于治疗二型糖尿病。
TN1856	Leachianone A 里查酮 A	97938-31-3	99.79%
TN1856	Leachianone A (Isokurarinone) 是从槐花中分离的一种天然产物，可诱导细胞凋亡，具有抗疟疾、抗炎和细胞毒性作用。
T2389	Dapagliflozin 达格列净	461432-26-8	99.74%
T2389	Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，可促进尿液中葡萄糖的排泄，在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。
T2922	Phlorizin 根皮苷	60-81-1	99.58%
T2922	Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂，也是Na+/K+-ATPase 抑制剂，对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。
T9590	T-1095 化合物T-1095	209746-59-8	99.56%
T9590	T-1095 是一种口服有活性的Na+-葡萄糖协同转运蛋白选择性抑制剂，能够抑制 SGLT1 (IC50:22.8 µm) 及 SGLT2 (IC50:2.3 µm) 。它可用于研究糖尿病。
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate) 达格列净 (2S)-1,2-丙二醇水合物	960404-48-2	99.39%
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体，是竞争性葡萄糖协同转运蛋白2 抑制剂，可促进...
T3547	Sotagliflozin 化合物Sotagliflozin	1018899-04-1	99.37%
T3547	Sotagliflozin (LP-802034) 是有效的SGLT1/2抑制剂，用作抗糖尿病剂。
T4999	Ertugliflozin 埃格列净	1210344-57-2	99.27%
T4999	Ertugliflozin (PF-04971729) 是选择性的、口服有效的钠离子依赖的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，对h-SGLT2 的IC50值为 0.877 nM。Ertugliflozin 在2型糖尿病中有研究价值。
T34286	Remogliflozin etabonate 瑞格列净乙酸酯	442201-24-3	99%
T34286	Remogliflozin etabonate (GSK189075A) 是 regaliflozin 的前药和 SGLT2 抑制剂，对 hSGLT2、rSGLT2、rSGLT1 和 hSGLT1 的 Ki 值分别为 1.95、2.14、8.57 和 43.1μM。