Thiamine diphosphate analog 1, an analog of Thiamine diphosphate (the active form of vitaminB1 and a universal cofactor in key cellular pathways), mirrors the structure and potentially the function of its prototype.
4-Amino-5-(bromomethyl)-2-methylpyrimidine is a heterocyclic building block.1,2 It has been used in the synthesis of vitaminB1 analogs and thiaminephosphoric acid esters. |1. Abblard, J., Cronenberger, L., and Pacheco, H. Synthesis of the analogs of vitaminB1. Chim. Ther. 8(1), 98-110 (1973).|2. Leichssenring, G., and Joachim, S. The synthesis of thiaminephosphoric acid esters. Chem. Ber. 95, 767-772 (1962).