trpa1 in 1

TRPA1-IN-1 is a potent, selective antagonist of the TRPA1 channel, demonstrating significant oral bioavailability as a small molecule.

TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.

TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.

AMG-0347 (UNII-CD7L9290QR)是一种靶向TRPA1(瞬时受体电位锚蛋白1)离子通道的小分子抑制剂，是一种在感觉神经元中发现的受体，参与疼痛和环境刺激物的检测。AMG-0347通过阻断TRPA1的功能起作用，具有镇痛作用。

Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分，也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道，并在高浓度下抑制前者但不抑制后者。

Pico145 (HC-608) 是有效的瞬时受体电位通道蛋白 1 4 5 (TRPC1 TRPC4 TRPC5) 抑制剂，在细胞中，抑制 (-)-englerin A 活化TRPC4 TRPC5 通道的IC50分别为 0.349 和 1.3 nM。

GRC-17536 is an orally available, potent, and selective transient receptor potential anchor protein 1 (TRPA1) inhibitor that has been shown to be highly effective in the treatment of inflammation and neuropathic pain in animal models. The selectivity of G

2-Fluoro-4-iodo benzonitrile is a building block.1,2It has been used in the synthesis ofL. infantumtrypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors.12-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.2 1.Revuelto, A., Ruiz-Santaquiteria, M., de Lucio, H., et al.Pyrrolopyrimidine vs imidazole-phenyl-thiazole scaffolds in nonpeptidic dimerization inhibitors of Leishmania infantum trypanothione reductaseACS Infect. Dis.5(6)873-891(2019) 2.Vallin, K.S., Sterky, K.J., Nyman, E., et al.N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptorBioorg. Med. Chem. Lett.22(17)5485-5492(2012)

Supercinnamaldehyde 是一种瞬时受体电位锚蛋白1(TRPA1)激活剂，具有千的抗癌和抗菌活性。Supercinnamaldehyde 抑制NF-κB信号传导，通过Nrf2诱导诱导细胞保护反应和抑制炎症反应。

Wasabi Receptor Toxin通过延长TRPA1通道的开放时间并降低其Ca2+渗透性，从而激活该通道。该化合物被应用于急性与持续性疼痛研究领域。

TRPA1-IN-3 (compound 1) 作为一种有效的TRPA1抑制剂，主要应用于皮肤和呼吸道相关的研究领域。

(±)-Cannabichromene 是一种发现于大麻的 2,2-dimethyl-2H-chromene 衍生物。