5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative that possesses potent anti-bovine viral diarrhea virus activity. It serves as a valuable compound for the synthesis of lead compounds with such activity.
Asulacrine isethionate, also known as CI-921; NSC-343499; SN-21407, is a topoisomerase ll inhibitor with antineoplastic properties. Asulacrine isethionate inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis.
Asulacrine free base, also known as CI-921; NSC-343499; SN-21407, is a topoisomerase ll inhibitor with antineoplastic properties. Asulacrine free base inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis.
SN-28049 SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIalpha, suppression of topo I and inhibition of gene transcription from promoters with SP-1 sites. These actions may contribute to the promising experimental solid tumour anticancer activity of SN 28049.
Arachidonic acid leelamide is a phospholipase A2 inhibitor. Phospholipase A is a hydrolase responsible for the release of arachidonic acid from the sn2 position of phospholipids. The released arachidonic acid is then converted to mediators of inflammation