ODIPY Green 8-P2M is an innovative thiol-reactive fluorescence probe derived from the BODIPY fluorophore. Its fluorescence is significantly quenched by d-PeT and can be reactivated upon reacting with thiol, leading to an exceptionally high signal-to-noise ratio. This makes ODIPY Green 8-P2M valuable for detecting very low concentrations of protein in gels following SDS-PAGE [1].