pomalidomide

Pomalidomide (CC-4047) 是一种抗血管生成剂和免疫调节剂。Pomalidomide 是泛素 E3 连接酶 cereblon (CRBN) 的配体，常用于 PROTAC 产品的合成。

(S)-Pomalidomide is an inhibitor of angiogenesis and growth of B-cell neoplasias, which induces complete regressions of Burkitt's lymphoma cell tumors.

Pomalidomide-peg1-co2H是一种合成的 E3 连接酶配体-接头偶联物，包含基于 Pomalidomide 的 cereblon 配体和 2 单元 PEG 接头。

Pomalidomide-C2-acid 是 PROTAC 的组成部分。

Pomalidomide-PEG2-OH 能够合成用于靶向蛋白质降解和 PROTAC（蛋白水解靶向嵌合体）技术的分子。

Pomalidomide-PEG3-OH 能够合成用于靶向蛋白质降解和 PROTAC（蛋白水解靶向嵌合体）技术的分子。

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。

Pomalidomide-C2-NH2是一种合成的 E3 连接酶配体-linker 偶联物，。

Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 3 单元 PEG 的linker。

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.

Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate.

Pomalidomide-amido-C4-amido-C6-NH-Boc, a synthesized conjugate, is a ligand-linker incorporating the cereblon ligand based on Pomalidomide and a PROTAC technology linker.

Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物，用于 PROTAC 技术中。

Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].

Pomalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand based on Pomalidomide with a linker. This compound is instrumental in designing PROTAC BRD4 Degrader-1[1].

Pomalidomide-PEG2-Tos is a compound that consists of an E3 ligase ligand-linker conjugate. It is composed of a cereblon ligand conjugated to a two-unit PEG linker[1].

Pomalidomide-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Pomalidomide-PEG6-butyl iodide is a chemically synthesized conjugate compound that functions as an E3 ligase ligand-linker conjugate. It combines the cereblon ligand derived from Pomalidomide with a 6-unit PEG linker, which is commonly utilized in PROTAC technology[1].

Pomalidomide-C2-amide-C4-Br，一种包含Cereblon(CRBN) 配体（基于Pomalidomide）和1个 linker 的E3 连接酶配体-linker 偶联物 (E3 Ligase Ligand-linker conjugate)，主要用于PROTAC的合成。

Pomalidomide-C2-NHCO-C6 是一类 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates)。该化合物主要应用于合成 PROTACFGFR2degrader 1。

Pomalidomide-6-5-6-I（Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide）在蛋白质降解剂的制造中起到关键作用，这些降解剂用于靶向蛋白质降解和PROTAC研究。