mucin

Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。

MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1.

Fudosteine 是一种半胱氨酸衍生物和粘液活性剂。它能够抑制 MUC5AC 基因表达，阻碍 MUC5AC 粘蛋白过度分泌。

Gatipotuzumab (PankoMab) 是一种与粘蛋白 1 肿瘤相关表位 （TA-MUC1） 结合的新型人源化单克隆抗体，具有潜在的抗肿瘤活性，可用于研究复发性上皮性卵巢癌。

Clivatuzumab MMAE(克利妥珠单抗 MMAE)是一种ADC，由人源化抗MUC1（mucin）的单克隆抗体和抗有丝分裂的细胞毒素MMAE组成，用于胰腺癌的研究。

Fexlamose是一种用于慢性阻塞性肺病 (COPD) 研究的介入雾化溶液，具有粘液溶解特性。

Sofituzumab（MMUC 1206A）是一款针对MUC16的重组人源化V-kappa型单克隆抗体。

Minretumomab（CC-49）是一种针对TAG-72（tumor-associated glycoprotein 72）的鼠源单克隆抗体，由B72.3抗体优化得到，可用于研究乳腺癌、结肠癌、肺癌和胰腺癌。

Gastric mucin 是一种能保护胃肠道免受酸、蛋白酶、致病微生物和机械创伤影响的糖蛋白。

Submandibularmucin是一种高分子量糖蛋白，常用于作为病毒酶神经氨酸酶的底物。

Pranlukast (ONO-1078) 是一种半胱氨酰白三烯受体 1 拮抗剂，可拮抗或减少支气管痉挛，用于哮喘研究。

Mucinase StcE 是产志贺毒素大肠杆菌 (Enterohemorrhagic Escherichia coli, EHEC) 分泌的金属蛋白酶，属于丝氨酸蛋白酶家族。在病原菌感染中，该酶通过特异性切割糖基化黏蛋白 (mucins) 的肽链骨架，起到关键作用。

Lipopolysaccharides, fromAkkermansia muciniphila (LPS, fromAkkermansia muciniphila) 是一种来源于嗜胶阿克曼氏菌 (Akkermansia muciniphila) 的内毒素。作为一种脂多糖内毒素和 TLR-4 激活剂，Lipopolysaccharides 可激活免疫系统的致病相关分子模式 (PAMP) 并诱导细胞分泌迁移体。它能够从革兰氏阴性菌外膜的外叶提取，结构包括抗原 O-特异性链、核心寡糖和脂质 A。

IQB-782 是一种粘液溶解剂，具有粘液溶解祛痰活性。IQB-782 抑制凝血酶活化性纤维蛋白溶解抑制剂，保护大鼠免受烟草烟雾引起的呼吸道阻塞，可降低体外胃粘蛋白悬浮液的粘度，可用于研究阻塞性肺疾病。

Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。

Benzyl-α-GalNAc (O-glycosylation-IN-1) 是 O-糖基化的有效抑制剂，用于减少细胞表面粘蛋白的含量。它抑制人胰腺癌细胞模型黏蛋白 O-糖基化的合成。

Coixol (MBOA) 是一种从薏苡仁中提取的多酚，有抗菌和抗肿瘤作用。

Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversibly converted to phosphatidylethanolamine by phosphatidylserine decarboxylase in the mitochondria. Phosphatidylserine binds to T cell immunoglobulin mucin type 1 (TIM-1) and TIM-4 receptors as well as brain-specific angiogenesis inhibitor 1 (BAI1), leading to anti-inflammatory and anti-atherosclerotic effects. It is also a cofactor involved in the activation of various signaling pathways through activation of protein kinase C, neutral sphingomyelinase, and c-Raf-1 protein kinase among others. Phosphatidylserine is externalized during apoptosis by scramblases in the plasma membrane as a signal for phagocytes to engulf the cell. Phosphatidylserines (bovine) is a mixture of bovine phosphatidylserines containing fatty acids with variable chain lengths at the sn-1 and sn-2 positions.

Deapioplatycodin D 是从桔梗中分离出的一种三萜皂苷，具有抗丙型肝炎病毒活性。

Talniflumate (Somalgen) 是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻滞剂，可减少动物模型和细胞培养中的粘蛋白合成和释放。它通过抑制环氧合酶，并抑制 Cl-/HCO3- 交换活性，具有抗炎作用。它还增加了远端肠梗阻综合征囊性纤维化小鼠模型的存活率。

Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。

Colistin adjuvant-1 是一种粘菌素佐剂 (colistin adjuvant)，对革兰氏阴性细菌具有增强的粘菌素增强活性。Colistin adjuvant-1 对 NF-κB 表现出抑制作用 (IC50: 0.209 μM)。

Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells. Ambroxol increases phenol red secretion, a marker of expectorant activity, in mice when administered at doses of 30, 60, or 120 mg kg. Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.

Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner. Guaifenesin increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing guaifenesin have been used as expectorants in the treatment of the common cold and chronic bronchitis.