购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空
筛选
已筛选:全部清除
TargetMol | Tags 通过 靶点 筛选
  • Sodium Channel
    (4)
  • Bombesin Receptor
    (2)
  • HIV Protease
    (2)
  • CRFR
    (1)
TargetMol | Tags 通过 货期 筛选
  • 现货
    (9)
  • 5日内发货
    (23)
  • 20日内发货
    (6)
  • 35日内发货
    (4)
筛选
搜索结果
TargetMol产品目录中 "

he 1

"的结果
  • 抑制剂&激动剂
    27
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    11
    TargetMol | Recombinant_Protein
  • 多肽产品
    11
    TargetMol | Peptide_Products
  • 天然产物
    1
    TargetMol | Natural_Products
  • 同位素
    1
    TargetMol | Isotope_Products
  • 检测抗体
    18
    TargetMol | Antibody_Products
  • KR-32568
    T36569852146-73-7
    KR-32568是一种钠 氢交换器1(NHE-1)抑制剂(IC50:230 nM)。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时,它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568(0.3mg kg)在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。
    • ¥ 341
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Rimeporide
    EMD-87580
    T5319187870-78-6
    Rimeporide (EMD-87580) 是有效的 Na+ H+交换泵 (NHE-1) 选择性抑制剂。
    • ¥ 631
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Rimeporide hydrochloride
    盐酸Rimeporide, EMD-87580 hydrochloride
    T5333187870-95-7
    Rimeporide hydrochloride (EMD-87580 hydrochloride) 是一种有效的 Na+ H+交换泵(NHE-1) 选择性抑制剂。
    • ¥ 1060
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • [D-Phe12,Leu14]-Bombesin acetate
    [D-Phe12,Leu14]-Bombesin acetate(108437-88-3 Free base)
    TP1916L1
    [D-Phe12,Leu14]-Bombesin acetate 抑制铃蟾素刺激的分泌。
    • ¥ 833
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Cariporide
    卡立泊来德, HOE-642
    T2238159138-80-4
    Cariporide (HOE-642) 是一种选择性的Na+ H+交换抑制剂。
    • ¥ 279
    In stock
    规格
    数量
  • [Nphe1]Nociceptin(1-13)NH2 TFA
    T75909
    [Nphe1]Nociceptin(1-13) NH2 TFA 是一种 Nociceptin orphanin FQ (NC)内源性配体,是一种选择性和竞争性的 ociceptin receptor 拮抗剂,不具有激动剂活性。[Nphe1]nociceptin(1-13)NH2 选择性结合重组 nociceptin 受体(pKi=8.4),拮抗 nociceptin 对 CHO 细胞中 cAMP 积累的抑制作用(pA2=6.0)。[Nphe1]Nociceptin(1-13)NH2 有可能作为一种止痛试剂。
    • 待询
    规格
    数量
  • (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
    T76602150646-45-0
    (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) 作为一种CRF拮抗剂,能有效阻断IL-1a诱发的黄体生成素 (LH) 抑制作用。
    • 待询
    规格
    数量
  • (Phe13,Tyr19)-MCH (human, mouse, rat)
    T76632160201-86-5
    (Phe13,Tyr19)-MCH (human, mouse, rat) 作为一种高效的 SLC-1 与 S643b 受体配体,可充当这两种受体的激动剂。
    • 待询
    规格
    数量
  • Stressin I TFA
    Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA
    T81081
    Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA,作为CRF1受体选择性激动剂,具有1.7 nM的Ki值。该化合物能够促使大鼠促肾上腺皮质激素(ACTH)水平提升。
    • 待询
    规格
    数量
  • 4-Hydroxyestrone
    4-羟雌甾酮
    T94543131-23-5
    4-Hydroxyestrone 是一种内源性雌激素代谢物,可强烈保护神经元细胞免受氧化损伤。
    • ¥ 3770
    5日内发货
    规格
    数量
  • [D-Phe12,Leu14]-Bombesin
    TP1916108437-88-3
    Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
    • ¥ 880
    待询
    规格
    数量
  • [Nphe1]Nociceptin(1-13)NH2
    TP1987267234-08-2
    Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
    • ¥ 2310
    待询
    规格
    数量
  • [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
    TP1988213130-17-7
    Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively)
    • ¥ 2310
    待询
    规格
    数量
  • [D-Phe12]-Bombesin
    TP2239108437-87-2
    Bombesin receptor antagonist
    • ¥ 2085
    待询
    规格
    数量
  • [D-Phe12]-Bombesin acetate
    [D-Phe12]-Bombesin acetate(108437-87-2 free base)
    TP2239L
    [D-Phe12]-Bombesin acetate 抑制铃蟾素刺激的分泌。
    • ¥ 1413
    In stock
    规格
    数量
  • D18
    T613902230218-36-5
    D18 is an immune modulator that acts as a dual agonist for TLR7 8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1 PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].
    • ¥ 10600
    10-14周
    规格
    数量
    TargetMol | Inhibitor Hot
  • AMD 3465
    GENZ-644494
    T14208185991-24-6
    AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC
    • ¥ 10600
    6-8周
    规格
    数量
  • N-desmethyl Rosuvastatin (sodium salt hydrate)
    T35718
    N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS)Anal. Bioanal. Chem.402(3)1217-1227(2012) 2.Bai, X., Wang, X.P., He, G.D., et al.Simultaneous determination of rosuvastatin, rosuvastatin-5 S-lactone, and N-desmethyl rosuvastatin in human plasma by UPLC-MS/MS and its application to clinical studyDrug Res. (Stuttg.)68(6)328-334(2018)
    • ¥ 4970
    35日内发货
    规格
    数量
  • Palmitic acid-1,2,3,4-13C4
    Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
    T35790287100-89-4
    Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellular proteins, promotes protein-vesicle interactions, and regulates various G protein-coupled receptor functions.1Red blood cell palmitic acid levels are increased in patients with metabolic syndrome compared to patients without metabolic syndrome and are also increased in the plasma of patients with type 2 diabetes compared to individuals without diabetes.3,4 1.Fatima, S., Hu, X., Gong, R.-H., et al.Palmitic acid is an intracellular signaling molecule involved in disease developmentCell. Mol. Life Sci.76(13)2547-2557(2019) 2.Santos, M.J., López-Jurado, M., Llopis, J., et al.Influence of dietary supplementation with fish oil on plasma fatty acid composition in coronary heart disease patientsAnn. Nutr. Metab.39(1)52-62(1995) 3.Yi, L.-Z., He, J., Liang, Y.-Z., et al.Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDAFEBS Lett.580(30)6837-6845(2006) 4.Kabagambe, E.K., Tsai, M.Y., Hopkins, P.N., et al.Erythrocyte fatty acid composition and the metabolic syndrome: A National Heart, Lung, and Blood Institute GOLDN studyClin. Chem.54(1)154-162(2008)
    • 待估
    35日内发货
    规格
    数量
  • Epitalon (acetate)
    T35993307297-40-1
    Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.4References1. Khavinson, V.K., and Myl'nikov, S.V. Effect of epithalone on the age-specific changes in the time course of lipid peroxidation in Drosophila melanogaster. Bull. Exp. Biol. Med. 130(11), 1116-1119 (2000).2. Anisimov, V.N., Khavinson, V.K., Popovich, I.G., et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology 4(4), 193-202 (2003).3. Kossoy, G., Anisimov, V.N., Ben-Hur, H., et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H He mice. In Vivo 20(2), 253-257 (2006).4. Khavinson, V., Goncharova, N., and Lapin, B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro. Endocrinol. Lett. 22(4), 251-254 (2001). Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.4 References1. Khavinson, V.K., and Myl'nikov, S.V. Effect of epithalone on the age-specific changes in the time course of lipid peroxidation in Drosophila melanogaster. Bull. Exp. Biol. Med. 130(11), 1116-1119 (2000).2. Anisimov, V.N., Khavinson, V.K., Popovich, I.G., et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology 4(4), 193-202 (2003).3. Kossoy, G., Anisimov, V.N., Ben-Hur, H., et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H He mice. In Vivo 20(2), 253-257 (2006).4. Khavinson, V., Goncharova, N., and Lapin, B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro. Endocrinol. Lett. 22(4), 251-254 (2001).
    • ¥ 307
    待询
    规格
    数量
  • YW3-56
    YW3-56
    T361071374311-17-7
    YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et al. Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and t he mammalian target of rapamycin complex 1 activity. J Biol Chem. 2012 Jul 27;287(31):25941-53.
    • ¥ 17200
    10-14周
    规格
    数量
  • Benzovindiflupyr
    T368221072957-71-1
    Benzovindiflupyr is a fungicide.1It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH; IC50= 5.2 nM), and mycelial growth ofS. sclerotiorum(EC50= 0.011 μg/ml). Benzovindiflupyr (60 μg/ml) completely protects eggplant leaves fromS. sclerotioruminfection. Formulations containing benzovindiflupyr have been used to control various fungal diseases in agriculture. 1.Gao, Y., He, L., Zhu, J., et al.The relationship between features enabling SDHI fungicide binding to the Sc-Sdh complex and its inhibitory activity against Sclerotinia sclerotiorumPest Manag. Sci.76(8)2799-2808(2020)
    • 待估
    35日内发货
    规格
    数量
  • 1-Hydroxy-ibuprofen
    T3821553949-53-4
    1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1]. [1]. Yujie He, et al. Metabolism of Ibuprofen by Phragmites australis: Uptake and Phytodegradation. Environ Sci Technol. 2017 Apr 18;51(8):4576-4584. [2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.
    • 待估
    35日内发货
    规格
    数量
  • NS309
    T461218711-16-5
    NS309 是选择性钙依赖性钾离子通道 SK IK 的激活剂,在 BK 通道上没有激活作用。
    • ¥ 186
    In stock
    规格
    数量