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Anti-NPC2 Antibody (6B875)
还可以产品编号 TMAY-02564
Anti-NPC2 Antibody (6B875) 是一种 Mouse 抗体，靶向 NPC2。Anti-NPC2 Antibody (6B875) 可用于 IHC-P。
Anti-NPC2 Antibody (6B875)
Anti-NPC2 Antibody (6B875)
还可以产品编号 TMAY-02564
Anti-NPC2 Antibody (6B875) 是一种 Mouse 抗体，靶向 NPC2。Anti-NPC2 Antibody (6B875) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-NPC2 Antibody (6B875) is a Mouse antibody targeting NPC2. Anti-NPC2 Antibody (6B875) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6B875 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human NPC2 in human epididymis with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human NPC2 in human kidney with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NPC2 (rh NPC2; TMPY-01114; NP_006423.1; Met1-Leu151). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| 研究背景 | Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human NPC2 Protein (TMPY-01114) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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