furin

BOS-318是一种Furin 抑制剂，IC50值为1.9 nM，并且具有缓慢解离，高选择性，细胞通透性等特点。

Hexa-D-arginine 是稳定的furin 抑制剂，能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a furin inhibitor with Ki values of 0.106 μM for furin, 0.58 μM for PACE4, and 13.2 μM for PC1.

Pyrazofurin is a pyrimidine nucleoside analogue, inhibits cell proliferation and DNA synthesis in cells by inhibiting UMP synthase. Pyrazofurin is a sensitive orotate-phosphoribosyltransferase inhibitor (IC50s between 0.06-0.37 µM in the cell lines Hep-2,

Selenazofurin is an antiviral compound. Selenazofurin inhibits the cytopathic effect and yield of influenza A NWS 33 virus with 50% effective dose ranges of 0.7 to 1.4 micrograms ml.

Ammifurin is a Furocoumarin mixture used in treatment of vitiligo.

Tiazofurin (NSC-286193) 是一种合成的核苷类似物，显示出抗肿瘤活性。 它在细胞内合成为 tiazole-4-carboxamide adenine dinucleotide (TAD)，TAD 可有效抑制 IMP 脱氢酶。

Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes.

SSM 3 trifluoroacetate is a potent furin inhibitor (EC50= 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83in vitro.

SSM3 TFA is a potent furin inhibitor, blocking furin-dependent cell surface processing of anthrax protective antigen-83 in vitro..

MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.

Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) 是一种合成的荧光底物，可被furin 蛋白酶有效裂解。

SSM3 tetraTFA hydrate为有效的furin抑制剂，具有54 nM的EC50和12 nM的Ki。该化合物可有效阻断furin依赖的炭疽毒素保护antigen-83在细胞表面的处理。

Histatin-3是一肽类物质，由32个氨基酸残基构成，表现出显著的抗菌活性。作为前蛋白转化酶1(PC1)的底物，Histatin-3在Arg25位点的羧基端被该蛋白酶特异性切割（HRGYR降低SN）。此外，Histatin-3亦作为中等效力的、可逆的以及具竞争性的抑制剂，能够抑制弗林蛋白酶介导的五肽pGlu-Arg-Thr-Lys-Arg-MCA荧光底物的裂解，其抑制常数Ki大约为1.98μM。

DEC-RVRK-CMK为一种小型合成抗病毒化合物，具不可逆性及细胞渗透性，作为竞争性弗林蛋白酶抑制剂，该化合物对寨卡病毒(ZIKV)和日本脑炎病毒(JEV)显示出显著的抗病毒活性。

Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in

IN-2-LF, an inhibitor of lethal factor, also demonstrates inhibitory activity against furin, possessing an IC50 of 2 μM. Moreover, when used alongside D6R [1], IN-2-LF significantly enhances protection from anthrax lethal toxin.