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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Furin Antibody (1V361)

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货号 TMAB-06208

Anti-Furin Antibody (1V361) 是一种 Rabbit 抗体，靶向 Furin。Anti-Furin Antibody (1V361) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Furin Antibody (1V361)

Anti-Furin Antibody (1V361)

一键复制产品信息
Rating icon 还可以
货号 TMAB-06208

Anti-Furin Antibody (1V361) 是一种 Rabbit 抗体，靶向 Furin。Anti-Furin Antibody (1V361) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

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产品描述
Anti-Furin Antibody (1V361) is a Rabbit antibody targeting Furin. Anti-Furin Antibody (1V361) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
1V361
反应种属
Human,Mouse (predicted:Rat)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-200; IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Golgi apparatus > trans-Golgi network membrane. Cell membrane. Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
组织特异性Seems to be expressed ubiquitously.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Furin is a calcium-dependent serine endoprotease that belongs to the subtilisin-like proprotein convertase family. The members of this family process latent precursor proteins into their biologically active products. Furin cleaves at paired basic amino acid processing sites within proparathyroid hormone, transforming growth factor β 1 precursor, proalbumin, pro-β-secretase, membrane type-1 matrix metalloproteinase, β subunit of pro-nerve growth factor and von Willebrand factor. Furin can directly cleave proMMP-2 within the ttrans-Golgi network leading to an inactive form of matrix metalloproteinase-2 (MMP-2). Furin is synthesized as an inactive zymogen that may minimize the occurrence of premature enzymatic activity that would lead to alternative protein activation or degradation. The inhibitory mechanism is based on the presence of an inactivating prosegment at the NH2 terminal of the Furin. After initial autocatalytic cleavage, the prosegment remains tightly associated until it reaches the trans-Golgi network where the dissociation of the prosegment and activation of furin occurs.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Furin
抗原种属
Human
基因名称
FURIN
基因ID
5045
蛋白名称
Furin
Uniprot ID
P09958
功能
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
化学信息
分子量Theoretical: 74 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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