eukaryotic translation initiation factor 3

Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.

ZMF-24 是一种针对BT-549和MDA-MB-231细胞的TNBC抑制剂，IC50值分别为0.22 μM和0.44 μM。该化合物通过抑制真核翻译起始因子3亚基D(EIF3D)来破坏TNBC的能量供应，并通过促进持续的内质网应激，刺激TNBC细胞发生凋亡(apoptosis)。