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eukaryotic translation initiation factor 3

产品编号 TP2247 CAS TP2247

Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.

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eukaryotic translation initiation factor 3 Chemical Structure

eukaryotic translation initiation factor 3, CAS TP2247

规格	价格/CNY	货期
1 mg	￥ 483	待询
5 mg	￥ 1,383	待询
10 mg	￥ 2,283	待询
25 mg	￥ 3,183	待询

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生物活性

化学信息

存储 & 溶解度

产品描述	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.
体外活性	PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. Amplification of the EIF3S3 gene is common in late-stage prostate cancer suggesting that it may be functionally involved in the progression of the disease. A recent study shows that eukaryotic translation initiation factor 3 subunit 3 does not seem to be over-represented independent of c-myc in prostate cancer [2][3][4].
体内活性	In mammals, Eukaryotic translation initiation factor 3 is the largest scaffolding initiation factor, made up of 13 subunits (a-m). It is rough ~750 kDa and it controls the assembly of40S ribosomal subunit on mRNA that has a 5' cap or an IRES (Internal Ribosomal Entry Site). Eukaryotic translation initiation factor 3 uses the eIF4F complex or IRES from viruses to position the mRNA strand near the exit site of the 40S ribosome subunit, thus promoting the assembly of the pre-initiation complex [1].

分子量	1101.32
分子式	C47H84N14O14S
CAS No.	TP2247

存储

keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: ≥110.1mg/mL

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剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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