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抑制剂&激动剂
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  • 抑制剂&激动剂
    22
    TargetMol | Inhibitors_Agonists
  • 化合物库
    1
    TargetMol | Compound_Libraries
  • 重组蛋白
    18
    TargetMol | Recombinant_Protein
  • 多肽产品
    1
    TargetMol | Peptide_Products
  • 天然产物
    4
    TargetMol | Natural_Products
  • 试剂盒
    1
    TargetMol | Reagent_Kits
  • 同位素
    1
    TargetMol | Isotope_Products
  • 检测抗体
    7
    TargetMol | Antibody_Products
  • Ciliobrevin D
    T149651370554-01-0
    Ciliobrevin D 是细胞渗透性,可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。
    • ¥ 528
    In stock
    规格
    数量
  • (-)-blebbistatin
    (S)-(-)-Blebbistatin
    T6038856925-71-8
    (-)-Blebbistatin ((S)-(-)-Blebbistatin) 是 blebbistatin 的 S 对映异构体。(-)-Blebbistatin 是一种肌球蛋白 II 抑制剂 (IC50=0.5-5 μM),具有有效性和选择性。(-)-Blebbistatin 可以用于抑制心肌肌球蛋白、非肌肉肌球蛋白II和骨骼肌肌球蛋白。
    • ¥ 226
    In stock
    规格
    数量
  • Blebbistatin
    (±)-Blebbistatin
    T21550674289-55-5
    Blebbistatin ((±)-Blebbistatin) 是一种非肌肉肌球蛋白 II(NMII)选择性和非肌肉肌球蛋白重链9(MYH9)特异性的抑制剂,可促进角膜内皮细胞 (CEC) 的定向迁移并加速伤口愈合,并保留了细胞连接的完整性和屏障功能。
    • ¥ 295
    In stock
    规格
    数量
  • RUVBL1/2 ATPase-IN-1
    T9882423128-55-6
    RUVBL1 2 ATPase-IN-1 是一种有效的 RUVBL1 2 ATPase 抑制剂,IC50 值分别为 6.0 和 7.7 μM。 RUVBL1 2 ATPase-IN-1 可用于癌症疾病的研究。
    • ¥ 2480
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Esomeprazole Magnesium
    (S)-Omeprazole magnesium, NEXIUM, 埃索美拉唑镁, (-)-Omeprazole magnesium
    T2686161973-10-0
    Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。
    • ¥ 138
    In stock
    规格
    数量
  • Esomeprazole Sodium
    埃索美拉唑钠, (S)-Omeprazole sodium
    T2686L161796-78-7
    Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌,在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。
    • ¥ 139
    In stock
    规格
    数量
  • Esomeprazole Magnesium trihydrate
    埃索美拉唑镁三水合物, 埃索美拉唑镁(三水), (S)-Omeprazole magnesium trihydrate
    T8386217087-09-7
    Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。
    • ¥ 113
    In stock
    规格
    数量
  • V-ATPase-IN-1
    T2004671243603-61-3
    V-ATPase-IN-1 (Compound 3b-03) 作为一种抑制Vacuolar-type H+-ATPases (V-ATPase) 的化合物,其IC50值为194.80 μM,能有效靶向V-ATPase亚基 A,其 Kd 值为0.803 μM。此外,该化合物对 M. separata 显示出较强的杀虫活性,其LC50值达到2.64 mM,对化学杀虫剂的研发具有重要意义。
    • ¥ 10600
    4-6周
    规格
    数量
  • Bafilomycin C1
    巴菲霉素C1
    T2259888979-61-7
    vacuolar H+-ATPases (V-ATPases) inhibitor
    • 待估
    35日内发货
    规格
    数量
  • Rutamycin
    Oligomycin D,A272,A 272,A-272
    T286261404-59-7
    Rutamycin is a macrolide antibiotic of the oligomycin group obtained from Streptomyces rutgersensis. It inhibits various ATPases and uncouples oxidative phosphorylation from electron transport.
    • ¥ 5860
    35日内发货
    规格
    数量
  • Concanamycin B
    T3611681552-33-2
    Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface.
    • ¥ 13262
    待询
    规格
    数量
  • (S)-nitro-Blebbistatin
    T36335856925-75-2
    (S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.
    • 待估
    35日内发货
    规格
    数量
  • para-amino-Blebbistatin
    T364002097734-03-5
    para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.5,6 The addition of a 4'-amino group increases its water solubility, decreases the inherent fluorescence, stabilizes the molecule to circumvent its degradation by prolonged blue light exposure, and decreases its phototoxicity while retaining the in vitro and in vivo activity of blebbistatin.7 para-amino-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer. |1. Várkuti, B.H., Képiró, M., Horváth, I.á., et al. A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci. Rep. 6:26141, (2016).|2. Straight, A.F., Cheung, A., Limouze, J., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299(5613), 1743-1747 (2003).|3. Kovács, M., Tóth, J., Hetényi, C., et al. Mechanism of blebbistatin inhibition of myosin II. J. Biol. Chem. 279(34), 35557-35563 (2004).|4. Limouze, J., Straight, A.F., Mitchison, T., et al. Specificity of blebbistatin, an inhibitor of myosin II. J. Muscle Res. Cell Motil. 25(4-5), 337-341 (2004).|5. Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem. Biophys. Res. Commun. 320(3), 1020-1025 (2004).|6. Sakamoto, T., Limouze, J., Combs, C.A., et al. Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Biochemistry 44(2), 584-588 (2005).|7. Verhasselt, S., Roman, B.I., Bracke, M.E., et al. Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs. Eur. J. Med. Chem. 136, 85-103 (2017).
    • 待估
    35日内发货
    规格
    数量
  • Manzamine A hydrochloride
    T38441104264-80-4
    Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
    • ¥ 6650
    待询
    规格
    数量
  • Inosine-5'-triphosphate trisodium salt
    三磷酸肌苷三钠盐, 肌苷-5'-三磷酸三钠盐, ITP, Inosine 5'-triphosphate trisodium salt
    T489735908-31-7
    Inosine-5'-triphosphate trisodium salt (ITP) 是三磷酸核苷,能够作为 ATPases 和 GTPases 的底物。
    • ¥ 116
    In stock
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    数量
  • Naja Mossambica Venom
    T75585
    Naja Mossambica Venom (Mozambique Spitting Cobra Venom) 是一种蛇毒,可从 Naja Mossambica 获得。Naja Pallida Venom 对Candida 物种具有抗真菌活性。Naja Mossambica Venom 提取物 (如磷脂酶 A2) 可抑制钠钾 ATP 酶活性。
    • 待询
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    数量
  • SPAI-1
    T76374131359-77-8
    SPAI-1,特异性单价阳离子ATP酶抑制剂,源自猪十二指肠。能体外抑制Na+,K+-ATP酶和H+,K+-ATP酶,同时刺激Mg2+-ATP酶。
    • 待询
    规格
    数量
  • (S)-3'-hydroxy Blebbistatin
    (−)-3'-hydroxy Blebbistatin​,meta-hydroxy-Blebbistatin,m-hydroxy-Blebbistatin
    T851552097136-42-8
    (S)-3'-hydroxy-Blebbistatin is a more stable and less phototoxic derivative of (–)-blebbistatin, retaining the latter's properties as a selective, cell-permeable inhibitor of non-muscle myosin II ATPases. Unlike its predecessor, (S)-3'-hydroxy-Blebbistatin exhibits reduced fluorescence, improving its utility in live cell imaging applications by diminishing degradation into cytotoxic intermediates under blue light exposure (450-490 nm). It effectively inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across various species with IC50 values ranging from 0.5-5 µM and shows minimal inhibition against smooth muscle myosin with an IC50 of 80 µM. This compound plays a critical role in preventing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells, mirroring the active (–)-blebbistatin enantiomer in mechanism and efficacy.
    • 待询
    8-10周
    规格
    数量
  • (S)-3'-amino Blebbistatin
    meta-amino Blebbistatin, (−)-3'-amino Blebbistatin, m-amino Blebbistatin
    T852572097141-18-7
    (S)-3'-amino Blebbistatin, retaining the active stereochemistry of the less stable and more phototoxic (–)-blebbistatin, serves as a refined selective cell-permeable inhibitor of non-muscle myosin II ATPases. This compound efficaciously inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across several species with IC50s ranging from 0.5-5 µM, and exhibits minimal inhibition against smooth muscle myosin (IC50= 80 µM). Its primary functions include obstructing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. (S)-3'-amino Blebbistatin overcomes (–)-blebbistatin’s limitation of rapid degradation under blue light (450-490 nm) exposure, which generates cytotoxic intermediates, thus posing a challenge for fluorescent live cell imaging applications. The introduction of a 3’-amino group to its structure notably reduces fluorescence while maintaining (–)-blebbistatin’s activity, making it a superior alternative for research purposes.
    • 待询
    8-10周
    规格
    数量
  • Caloxin 1C2
    T89159
    Caloxin 1C2 是一种针对PMCA(质膜Ca2+-ATPases)的特异性抑制剂,对PMCA4具有更高的选择性,相较于PMCA1、2及3.对PMCA4的Ki值是2.3 μM,而对PMCA1则为21 μM.此外,Caloxin 1C2对总Ca2+转移未显示显著影响,并能影响冠状动脉的收缩力.
    • 待询
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  • Esomeprazole sodium-d6
    TMIH-0222922731-04-2
    Esomeprazole sodium-d6 是 Esomeprazole sodium 的氘代化合物。Esomeprazole sodium 的 CAS 号为 161796-78-7。Esomeprazole sodium 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium通过抑制胃壁细胞中的H+, K+-ATPase来降低酸分泌,在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。
    • ¥ 3200
    5日内发货
    规格
    数量
  • Concanamycin C
    4'-O-de(aminocarbonyl)-Concanamycin A
    TN725981552-34-3
    Concanamycin C, a natural macrolide antibiotic, was initially isolated from Streptomyces and identified as an inhibitor of T-cell proliferation in response to concanavalin A (1,2). It exhibits cytotoxicity to fungi, including yeasts, by inhibiting vacuolar-type ATPases (3,4).
    • 待询
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