alcoholism

Clomethiazole (Distraneurin) 是口服GABAA 激动剂，可抑制人肝微粒体中的细胞色素 P450 异构体，CYP2A6 和 CYP2E1。它有抗惊厥作用，具有治疗惊厥性癫痫持续状态的潜力。

Milenperone (R 34009) 是一种新型抗侵袭化合物，可用于控制癫痫和酗酒患者行为障碍。

Naltrexone hydrochloride (Naltrexone HCl) 是一种合成的 opiate 拮抗剂，用于预防 opiate 成瘾和酗酒的复发。

Acamprosate 是一种口服活性原型神经调节剂。Acamprosate 可用于酒精依赖和酒精中毒的研究。

Double carbene can be used for the study of schizophrenia and alcoholism. It can block dopamine receptors in various parts of the brain and prevent the reduction of conditioned defense reflexes caused by the stimulation of the mid-brain part of the networ

Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner. [2] It has been used to induce thiamine deficiency in various disease models, including rat models of alcoholism and diencephalic amnesia, to study the effects of thiamine deficiency on disease pathology.[3] [4] Reference：[1]. Woolley, D.W., and White, A.G.C. Selective reversible inhibition of microbial growth with pyrithiamine. J. Exp. Med. 78(6), 489-497 (1943).[2]. Woolley, D.W. An enzymatic study of the mode of action of pyrithiamine (neopyrithiamine). J. Biol. Chem. 191(1), 43-54 (1951).[3]. Vetreno, R.P., Anzalone, S.J., and Savage, L.M. Impaired, spared, and enhanced ACh efflux across the hippocampus and striatum in diencephalic amnesia is dependent on task demands. Neurobiol. Learn Mem. 90(1), 237-244 (2008).[4]. Zahr, N.M., Sullivan, E.V., Rohlfing, T., et al. Concomitants of alcoholism: Differential effects of thiamine deficiency, liver damage, and food deprivation on the rat brain in vivo. Psychopharmacology (Berl) 233(14), 2675-2686 (2016).

Surinabant, a cannabinoid CB1 antagonist, is used potentially for the treatment of obesity and alcoholism.

LY-2940094, a nociceptin receptor antagonist, is used potentially for the treatment of major depressive disorder and alcoholism.

Amitifadine(DOV-21947, EB-1010) is an inhibitor of the so-called triple reuptake or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) and is an antidepressant drug candidate. Amitifadine reduces binge drinking and negative affect in an animal m

5-HT2A&5-HT2C agonist-1 (Example 2) 是一种选择性的5-HT2A和5-HT2C受体激动剂，其IC50值分别为196 nM和0.9 nM。本化合物主要应用于研究抑郁症、酒精依赖、烟草和可卡因成瘾、炎症、丛集性头痛、PTSD、癫痫等中枢神经系统相关疾病。

5-HT2 agonist-1 (Compound 24) 是一种选择性5-HT2A, 5-HT2B和5-HT2C激动剂，其IC50值分别为10 nM, 8.3 nM和1.6 nM。5-HT2 agonist-1 free base主要用于研究治疗抑郁症、酗酒、吸烟与可卡因依赖、炎症、丛集性头痛、创伤后应激障碍(PTSD)、癫痫以及其他中枢神经系统疾病。

ADX71441 is a GABAB positive allosteric modulator (PAM). ADX71441 increases urinary latencies and reduces the number of urinary events and the total and average urinary volumes. ADX71441 may also mitigate alcoholism and have analgesic effects in the bladd

5-HT2 agonist-1 (Compound 24) free base 是一种作用于5-HT2A, 5-HT2B和5-HT2C受体的激动剂，其IC50值分别为10 nM, 8.3 nM和1.6 nM。该化合物主要应用于研究抑郁症、酒精依赖、烟草及可卡因成瘾、炎症、丛集性头痛、创伤后应激障碍(PTSD)、癫痫以及其他中枢神经系统相关疾病。