Lithium orotate is an orally effective lithium supplement with low binding affinity, allowing it to bypass amyloid chelation in Alzheimer's disease (AD) mouse models. In these models, as well as in aged wild-type mice, lithium orotate prevents the deposition of Aβ plaques and the accumulation of phosphorylated tau proteins. It also reverses AD pathology, neuroinflammatory changes, and memory loss. Furthermore, lithium orotate is applicable in the research of alcoholism and Alzheimer's disease.

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