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Search Results for " psd-95 "

Targets Recommended: Others

14

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13112L1	Tat-NR2B9c acetate Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate	Others	Others
	Tat-NR2B9c acetate (NA-1 acetate) 是一种突触后密度 95 (PSD-95) 抑制剂，对 PSD-95d2 (PSD-95 PDZ domain 2) 和 PSD-95d1 的 EC50 值分别为 6.7 nM 和 670 nM。它破坏 PSD-95/NMDAR 相互作用，抑制 NR2A 和 NR2B 与 PSD-95 的结合，IC50 值分别为 0.5 μM 和 8 μM。它还抑制神经元一氧化氮合酶 (nNOS)/PSD-95 相互作用，并具有神经保护功效。
T13112	Tat-NR2B9c Tat-NR2Bct,NA-1	NO Synthase; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Tat-NR2B9c (NA-1) 是一种突触后密度-95（PSD-95）抑制剂，具有神经保护和抗癫痫作用。Tat-NR2B9c 可抑制PSD-95d2、 PSD-95d1 和 PSD-95，可阻止NMDA诱导的神经元NADPH氧化酶的激活，从而阻断超氧化物的产生，可减少中风后急性期的缺血性损伤。
T17293	ZL006	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	ZL006 是一种 nNOS/PSD-95 相互作用抑制剂，能够抑制 NMDA 受体介导的 NO 合成。
T7355	IC87201	Others; iGluR	Membrane transporter/Ion channel; Neuroscience; Others
	IC87201 是 PSD95-nNOS 相互作用的抑制剂，可抑制 nMDAR 诱导的一氧化氮和 cGMP 的形成，可用于缺血性中风和疼痛的研究。
T35924	Tat-NR2Baa Tat-NR2Baa
	Tat-NR2BAA is an inactive control peptide of Tat-NR2B9c. It shares a similar sequence with Tat-NR2B9c, but possesses a double-point mutation in the COOH terminal tSXV motif. This mutation renders Tat-NR2BAA unable to bind PSD-95. Tat-NR2B9c, on the other hand, is a membrane-permeable peptide that interferes with PSD-95/NMDAR binding. This interference leads to the decoupling of NR2B- and/or NR2A-type NMDARs from PSD-95[1][2].
T13112L	Tat-NR2B9c TFA NA-1 (TFA)	Others	Others
	Tat-NR2B9c TFA is a 20-aa peptide, and acts as an inhibitor of postsynaptic density-95 (PSD-95)(EC50 of 6.7 nM for PSD-95d2), and possesses neuroprotective efficacy.
T75838	PDZ1 Domain inhibitor peptide TFA
	PDZ1 Domain inhibitor peptide TFA，一种环状肽，以 β-Ala 内酰胺侧链为接头，专一性靶向 PSD-95 的 PDZ1 域。此化合物能干扰 GluR6/PSD-95 间的相互作用，通过与 GluR6 的 C 末端竞争，抑制其在 PDZ1 域的结合。
T76069	Tat-NR2Baa TFA
	Tat-NR2BAA TFA 是 Tat-NR2B9c 的对照肽 (control peptide)，没有活性。Tat-NR2BAA TFA 的序列与 Tat-NR2B9c 相似，但在 COOH 末端 tSXV 基序中有一个双点突变，这使得它无法结合 PSD-95。Tat-NR2B9c TFA 是一种可通透细胞膜的多肽，破坏 PSD-95/NMDAR 的结合。
T70232	3,4-Dephostatin
	3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.
TP2208	PDZ1 Domain inhibitor peptide	Others	Others
	Novel cyclic peptide that disrupts interaction between GluR6 and PSD-95
T69658	Ethyl-3,4-dephostatin
	Ethyl-3,4-dephostatin is a novel inhibitor of the interactions of CFTR-associated ligand and PSD-95/Dlg1/ZO-1 domain.
T28736	SCR-4026
	SCR-4026 is an inhibitor of the nNOS-PSD-95 interaction with neuroprotective activities. SCR-4026 also promotes neural stem cells to differentiate into neurons-like cells.
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...

化合物

Tat-NR2B9c acetate

Cat.No: T13112L1

Synonym: Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate

Target: Others

Cat.No: T13112

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

Cat.No: T17293

Target: NMDAR, iGluR

Cat.No: T7355

Target: Others, iGluR

Cat.No: T35924

Synonym: Tat-NR2Baa

Cat.No: T13112L

Synonym: NA-1 (TFA)

Target: Others

PDZ1 Domain inhibitor peptide TFA

Cat.No: T75838

Cat.No: T76069

3,4-Dephostatin

Cat.No: T70232

PDZ1 Domain inhibitor peptide

Cat.No: TP2208

Target: Others

Ethyl-3,4-dephostatin

Cat.No: T69658

Cat.No: T28736

Palmitic acid-1-13C

Cat.No: T35789

Palmitic acid-13C

Cat.No: T35791

Cat. No.	Product Name	Target	Signaling Pathways
T2S0389	Emodin-1-O-β-D-glucopyranoside 大黄素-1-O-Β-D-吡喃葡萄糖苷,大黄素-1-O-β-D-葡萄糖苷,Emodin-1-O-glucoside	Others	Others
	Emodin-1-O-β-D-glucopyranoside (Emodin-1-O-glucoside) 是一种非竞争性细菌神经氨酸酶抑制剂，IC50为 0.85 μM，提取自药用植物虎杖中。

天然产物

Emodin-1-O-β-D-glucopyranoside

Cat.No: T2S0389

Synonym: 大黄素-1-O-Β-D-吡喃葡萄糖苷,大黄素-1-O-β-D-葡萄糖苷,Emodin-1-O-glucoside

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00652	PSD-95 Protein, Rat, Recombinant (His) PSD95,SAP90,Disks large homolog 4,SAP-90,<...	Rat	E. coli
	Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the be...
TMPY-03750	CRIPT Protein, Human, Recombinant (His) HSPC139,SSMDF,cysteine-rich PDZ-binding protein	Human	E. coli
	CRIPT, also known as cysteine-rich PDZ-binding protein, belongs to the CRIPT family. It interacts with TUBB1. CRIPT also interacts strongly with the PDZ3 domain of members of the DLG4 family. It is involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. CRIPT is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. n heterologous cells, CRIPT causes a redistribution of PSD-95 to microtubules. In brain, CRIPT colo...
TMPK-00798	IGSF11 Protein, Mouse, Recombinant (His) Bt-IGSF,BtIGSF,IgSF11,VSIG3,Bt IGSF,CXADRL1,CT119	Mouse	HEK293 Cells
	Immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs).

重组蛋白

PSD-95 Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00652

Species: Rat

Expression System: E. coli

CRIPT Protein, Human, Recombinant (His)

Cat.No: TMPY-03750

Species: Human

Expression System: E. coli

IGSF11 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00798

Species: Mouse

Expression System: HEK293 Cells

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