store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TSPO ligand-1 对外周和中枢苯二氮卓受体有亲和力。TSPO ligand-1 是一种线粒体外膜跨膜结构域上与 AUTAC4 结合的蛋白,可诱导线粒体自噬 (autophagy) 促进胞内线粒体更新。TSPO ligand-1 参与胆固醇在胞内的转运,可作为脑损伤和神经变性的生物标志物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 现货 | ||
5 mg | ¥ 496 | 现货 | ||
10 mg | ¥ 828 | 现货 | ||
25 mg | ¥ 1,650 | 现货 | ||
50 mg | ¥ 2,480 | 现货 | ||
100 mg | ¥ 3,730 | 现货 | ||
500 mg | ¥ 7,850 | 现货 |
产品描述 | TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.TSPO ligand-1 is an AUTAC4-binding protein in the transmembrane domain of the outer mitochondrial membrane, which induces mitochondrial autophagy and promotes intracellular mitochondrial regeneration.TSPO ligand-1 is involved in intracellular cholesterol transport, and can be used as a biomarker for brain injury and neurodegeneration. TSPO ligand-1 is involved in intracellular cholesterol transport and can be used as a biomarker for brain damage and neurodegeneration. |
体外活性 |
In the context of selective activation of neurons in male C57Bl6/N mice, the TSPO ligand-1 gene is induced to increase expression. Additionally, under both physiological and psychopharmacological conditions, neuronal activation leads to increased TSPO levels in adult mice[2]. As the sole marker of glial cell activity in Alzheimer’s disease, TSPO ligand-1 can track the formation of different neural cells[4]. In the MA-10 Leydig cell line, TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus affects mitochondrial energy homeostasis[3]. |
分子量 | 283.71 |
分子式 | C16H10ClNO2 |
CAS No. | 4560-08-1 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (176.24 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5247 mL | 17.6236 mL | 35.2473 mL | 88.1181 mL |
5 mM | 0.7049 mL | 3.5247 mL | 7.0495 mL | 17.6236 mL | |
10 mM | 0.3525 mL | 1.7624 mL | 3.5247 mL | 8.8118 mL | |
20 mM | 0.1762 mL | 0.8812 mL | 1.7624 mL | 4.4059 mL | |
50 mM | 0.0705 mL | 0.3525 mL | 0.7049 mL | 1.7624 mL | |
100 mM | 0.0352 mL | 0.1762 mL | 0.3525 mL | 0.8812 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TSPO ligand-1 4560-08-1 Autophagy Inhibitor inhibitor inhibit