pentacyclic

Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷，可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子，并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。

Pomolic acid 是从野鸦椿中分离出来的一种五环三萜烯。它抑制肿瘤细胞的生长，诱导细胞凋亡，有用于前列腺癌的潜力。

Ilexgenin A 是一种五环三萜类化合物，提取自海南冬青，可用于研究炎症及癌症。

Mitoquidone 是一种新型的五环吡咯醌，是一种潜在的抗癌剂。Mitoquidone 在一系列实验性实体肿瘤模型中表现出良好的活性且不表现出明显的细胞毒性。

Ursolic acid (Prunol) 属于天然产物，是一种五环三萜羧酸，提取自毛喉杜鹃。Ursolic acid 具有抗肿瘤、抗炎、抗菌、降血糖等活性。

Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。

Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.

Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.

28-Aminobetulin 是一种五环三萜化合物，作为胆固醇合成抑制剂Betulin的衍生物。

Resistomycin（Geliomycin），一种五环多酮类抗生素，通过触发凋亡展现出强大的抗癌特性。

Tingenone is a pentacyclic triterpene. It induces peripheral antinociception due to opioidergic activation.

Acetylaleuritolic acid 是一种从小花加西亚叶中分离得到的一种五环三萜类化合物，植物代谢产物。它具有抗肿瘤特性，对P-388淋巴细胞白血病测试中显示出肿瘤抑制活性。

Madecassoside (Asiaticoside A) 是从崩大碗中分离出来的一种五环三萜，有抗炎症，抗氧化和抗衰老的作用。

Hopane-6α,7β,22-triol 是一种五环三萜类化合物，可用于生命科学研究

alpha-Boswellic acid 是一种从乳香中提取得到的五环三萜类化合物，具有抗惊厥和抗癌作用。在动物体内，它是预防和减少阿尔茨海默病标志物，可用于阿尔茨海默病的研究。

Lantanolic acid is a pentacyclic triterpenoid from the leaves of Lantana montevidensis.

Ursonic Acid (TOS-BB-0966) 是一种天然三萜酸，属于熊果烷三萜类，其结构基于五环熊果烷骨架。 它具有作为 HIV-1 蛋白酶抑制剂的潜力。

Alpha-Hederin (Tauroside E) 是存在于黑种草种子中的一种单桥糖三萜皂苷，具有抗肿瘤作用。它可通过激活线粒体依赖性途径抑制胃癌细胞增殖，诱导凋亡，并有活性氧生成和谷胱甘肽减少。

2,3-Indolobetulinic glycine amide is a pentacyclic triterpene and derivative of betulinic acid .1It has been used in the synthesis of betulinic acid derivatives with anticancer activity. 1.Kumar, V., Rani, N., Aggarwal, P., et al.Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivativesBioorg. Med. Chem. Lett.18(18)5058-5062(2008)

N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017)

Betulinic acid propargyl ester is a pentacyclic lupane triterpene and alkyne derivative of betulinic acid .1,2It has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives.

Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2

2,3-Indolobetulin is a pentacyclic triterpenoid and derivative of betulin .1It has been used in the synthesis of α-glucosidase inhibitors. 1.Khusnutdinova, E.F., Smirnova, I.E., Kazakova, O.B., et al.Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitorsMed. Chem. Res.262732-2742(2017)

2,3-Indolobetulonic acid is pentacyclic triterpenoid derivative of betulonic acid and an inhibitor of α-glucosidase (IC50= 1.8 μM).1 1.Khusnutdinova, E.F., Smirnova, I.E., Kazakova, O.B., et al.Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitorsMed. Chem. Res.262732-2742(2017)