rno-miR-122-5p agomir is a specially chemically modified miRNA mimic. The mature miRNA strand undergoes full-chain methoxy modification, with 2 and 4 thio modifications at the 5' and 3' ends, respectively, and a high-affinity cholesterol modification attached at the 3' end. This miRNA agomir simulates endogenous miRNA and enhances miRNA activity. Compared to ordinary mimics, miRNA agomirs exhibit higher stability and inhibitory effects in animal experiments, making them more capable of passing through cell membranes and tissue spaces to accumulate in target cells.