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Pyronaridine

Name: Pyronaridine
Brand: TargetMol
SKU: T5493
Price: 308 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 咯萘啶

货号 T5493Cas号 74847-35-1 一键复制产品信息纯度: 99.90%

很棒

Pyronaridine 是一种具有口服活性的、含甘露醇的抗疟疾化合物，通过干扰红细胞内疟疾寄生虫(疟原虫)的复制而起作用。Pyronaridine 常与其他药联用来治疗疟疾，对对 P. falciparum 和 Echinococcus granulosus 具有抗感染活性。

Pyronaridine

一键复制产品信息

很棒

纯度: 99.90%

货号 T5493Cas号 74847-35-1

别名 咯萘啶

规格	价格	库存
1 mg	¥ 308	现货
5 mg	¥ 636	现货
10 mg	¥ 912	现货
25 mg	¥ 1,630	现货
50 mg	¥ 2,330	现货
100 mg	¥ 3,360	现货
200 mg	¥ 4,690	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.90%

性状: Solid

资源下载: COA LCMS产品操作手册

产品介绍

Pyronaridine AI Summary

Pyronaridine exhibits potent antimalarial activity against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum, with IC50 values ranging from 3.6 nM to 9.1 nM. It also demonstrates efficacy against various stages of malaria parasites, including ring stage, asexual stage, and gametocytes, with IC50 values as low as 0.72 nM for Plasmodium ovale and 1.6 nM for Plasmodium vivax. Additionally, Pyronaridine shows a high selectivity index, indicating a favorable therapeutic window over cytotoxic effects on human HEK293 cells, where the IC50 value is 1800.0 nM. Moreover, the compound exhibits inhibitory effects on ookinete formation in Plasmodium berghei, mature gamete exflagellation in Plasmodium falciparum, and sporozoite invasion of human HepG2 cells in Plasmodium yoelii. The therapeutic index value suggests potential efficacy, further confirmed by its ability to inhibit heme polymerization in Plasmodium falciparum. Furthermore, the compound demonstrates antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 5.0 µg/mL and antiviral activity against Ebolavirus and SARS-CoV-2, albeit with limited effectiveness..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combination with other drugs to treat malaria and has infective activity against P. falciparum and Echinococcus granulosus.
别名	咯萘啶

化学信息

分子量	518.05
分子式	C₂₉H₃₂ClN₅O₂
CAS No.	74847-35-1
Smiles	N(C1=C2C(=NC3=C1C=CC(Cl)=C3)C=CC(OC)=N2)C4=CC(CN5CCCC5)=C(O)C(CN6CCCC6)=C4
密度	1.37g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 6.25 mg/mL (12.06 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9303 mL	9.6516 mL	19.3032 mL	96.5158 mL
5 mM	0.3861 mL	1.9303 mL	3.8606 mL	19.3032 mL
10 mM	0.1930 mL	0.9652 mL	1.9303 mL	9.6516 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。