规格

价格

库存

数量

1 mg

¥ 1,490

现货

5 mg

¥ 3,730

现货

10 mg

¥ 5,320

现货

25 mg

¥ 7,850

现货

50 mg

¥ 10,800

现货

100 mg

¥ 14,500

现货

200 mg

¥ 19,600

现货

生物活性

产品描述	PAOPA is a novel dopamine D2 receptor modulator and L-proline-L-leucine-glycine amide (PLG) peptide mimetic that prevents and reverses behavioral and biochemical abnormalities in preclinical animal models of schizophrenia sensitized to amphetamine. PAOPA has been used in the study of schizophrenia and extrapyramidal dysfunction.
体外活性	10 μM PAOPA，处理1.5小时能在D2/eYFP标记的细胞中增加GRK2的纹状体表达，促进arrestin-3、磷酸化的ERK1和ERK2的表达。 10 μM PAOPA，处理48小时则促进D2/eYFP标记细胞中D2受体的内化。[1]
体内活性	在慢性给药中，腹腔注射 1 mg/kg PAOPA，每日一次持续45天，能够增强小鼠中D2受体的调节作用，并上调下游分子（如GRK2、arrestin-3和磷酸化的ERK 1/2）的表达。[1]

化学信息

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (176.96 mM), Sonication is recommended.

H2O: <25.43 mg/mL, Sonication is recommended.

溶液配制表

DMSO