NPY 5RA972

Name: NPY 5RA972
Brand: TargetMol
SKU: T23087
Price: 282 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.56%

货号 T23087Cas号 439861-56-0

NPY 5RA972 是一种神经肽 Y Y5 受体拮抗剂

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NPY 5RA972

一键复制产品信息

很棒

纯度: 99.56%

货号 T23087Cas号 439861-56-0

NPY 5RA972 是一种神经肽 Y Y5 受体拮抗剂

规格	价格	库存
1 mg	¥ 282	现货
5 mg	¥ 708	现货
10 mg	¥ 1,130	现货
25 mg	¥ 2,260	现货
50 mg	¥ 3,350	现货
100 mg	¥ 4,860	现货

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产品介绍

NPY 5RA972 AI Summary

NPY 5RA972 is a highly potent binder to the human Neuropeptide Y receptor Y5 (NPY5), with a binding affinity IC50 of 3.0 nM and functional antagonism in cellular Ca flux assays with an IC50 of 6.0 nM. It also shows an IC50 of 37.0 nM in functional antagonism in vitro assays. The compound demonstrates 70.0% inhibition on 5-HT2b and adenosine transport at concentrations higher than 10 µM, affecting receptors Y1, Y2, Y4, and 80 others. It has notable pharmacokinetic properties, including a bioavailability of 76.0% following oral administration at 30 µmol/kg, a Cmax of 35000 nM, and a Tmax of 1 hour. With a LogD7.4 value of 3.5 and solubility of 8300 nM in pH 7.4 buffer, NPY 5RA972 demonstrates high lipophilicity and moderate aqueous solubility, which could impact its distribution and permeation within biological systems. Additionally, NPY 5RA972 exhibits modest antiviral activity. It inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 µM with an inhibition rate of 18.95% after 48 hours, and VERO-6 cells with an inhibition rate of 0.7% under similar conditions. Furthermore, it shows 6.369% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM, indicating potential utility in targeting virus replication processes. The compound also displays inhibitory activity against human HDAC6, demonstrating 21.57% inhibition with a commercial peptide substrate and 12.45% with a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NPY 5RA972 is a neuropeptide Y Y5 receptor antagonist

化学信息

分子量	351.44
分子式	C₂₁H₂₅N₃O₂
CAS No.	439861-56-0
Smiles	CC(C)n1c2ccccc2c2c(C)c(NC(=O)N3CCOCC3)ccc12
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 24.17 mg/mL (68.77 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8454 mL	14.2272 mL	28.4544 mL	142.2718 mL
5 mM	0.5691 mL	2.8454 mL	5.6909 mL	28.4544 mL
10 mM	0.2845 mL	1.4227 mL	2.8454 mL	14.2272 mL
20 mM	0.1423 mL	0.7114 mL	1.4227 mL	7.1136 mL
50 mM	0.0569 mL	0.2845 mL	0.5691 mL	2.8454 mL