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ML337

Name: ML337
Brand: TargetMol
SKU: T23003
Price: 256 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T23003Cas号 1443118-44-2

别名 ML 337

ML337 是 mGlu3 的负变构调节剂，IC50 为 593 nM。

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ML337

一键复制产品信息

很棒

纯度: 99.83%

货号 T23003 别名 ML 337Cas号 1443118-44-2

ML337 是 mGlu3 的负变构调节剂，IC50 为 593 nM。

规格	价格	库存
1 mg	¥ 256	现货
5 mg	¥ 648	现货
10 mg	¥ 987	现货
25 mg	¥ 2,180	现货
50 mg	¥ 3,190	现货
1 mL x 10 mM (in DMSO)	¥ 519	现货

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产品介绍

ML337 AI Summary

ML337 exhibits various bioactivities, including high binding affinity and inhibition percentages towards the human 5-HT2B receptor and human DAT. It is characterized by good solubility in PBS and shows a high percentage of plasma protein binding in both mouse and human plasma, with a low fraction unbound in human, mouse, and rat plasma. The compound demonstrates high intrinsic clearance in rat liver microsomes and does not significantly inhibit cytochrome P450 enzymes (CYP2D6, CYP3A4, CYP2C9, CYP1A2) at concentrations above 30000 nM. Additionally, ML337 acts as a negative allosteric modulator of rat mGlu2 and mGlu3 receptors, and exhibits potency as a negative allosteric modulator of the Metabotropic Glutamate Receptor mGluR3 with an IC50 value of 509.13 nM in assays for mGluR3 function..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.
靶点活性	mGluR3:593 nM (IC50)
别名	ML 337

化学信息

分子量	353.39
分子式	C₂₁H₂₀FNO₃
CAS No.	1443118-44-2
Smiles	COc1ccc(cc1)C#Cc1ccc(C(=O)N2CCC[C@@H](O)C2)c(F)c1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 31.8 mg/mL (89.99 mM), Sonication is recommended.

Ethanol: < 7.07 mg/mL, Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2 mg/mL (5.66 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8297 mL	14.1487 mL	28.2973 mL	141.4867 mL
5 mM	0.5659 mL	2.8297 mL	5.6595 mL	28.2973 mL
10 mM	0.2830 mL	1.4149 mL	2.8297 mL	14.1487 mL
20 mM	0.1415 mL	0.7074 mL	1.4149 mL	7.0743 mL
50 mM	0.0566 mL	0.2830 mL	0.5659 mL	2.8297 mL