规格

价格

库存

数量

5 mg

¥ 7,662

待询

10 mg

¥ 13,332

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25 mg

¥ 27,912

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生物活性

产品描述

MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].

体外活性

MD-222 (1-30 nM; 1-2 hours) treatment shows very effective in reducing the levels of MDM2 protein and increasing the levels of p53 in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells[1]. MD-222 (30-100 nM; 6 hours) is effective in increasing the expression of several p53-targeted genes, such as MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong activation of p53[2]. MD-222 (4 days) shows cell growth inhibitory activity in RS4;11 cells with an IC50 of 5.5 nM, and has no effect on RS4;11/IRMI-2, MDA-MB-231 and MDA-MB-468 cells[1].

化学信息

分子量	893.84
分子式	C₄₈H₄₇Cl₂FN₆O₆
CAS No.	2136246-72-3
密度	1.46 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200 mg/mL (223.75 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 5 mg/mL (5.59 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1188 mL	5.5938 mL	11.1877 mL	55.9384 mL
5 mM	0.2238 mL	1.1188 mL	2.2375 mL	11.1877 mL
10 mM	0.1119 mL	0.5594 mL	1.1188 mL	5.5938 mL
20 mM	0.0559 mL	0.2797 mL	0.5594 mL	2.7969 mL
50 mM	0.0224 mL	0.1119 mL	0.2238 mL	1.1188 mL
100 mM	0.0112 mL	0.0559 mL	0.1119 mL	0.5594 mL