Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 7,662 | 待询 | ||
10 mg | ¥ 13,332 | 待询 | ||
25 mg | ¥ 27,912 | 待询 |
产品描述 | MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2]. |
体外活性 | MD-222 (1-30 nM; 1-2 hours) treatment shows very effective in reducing the levels of MDM2 protein and increasing the levels of p53 in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells[1]. MD-222 (30-100 nM; 6 hours) is effective in increasing the expression of several p53-targeted genes, such as MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong activation of p53[2]. MD-222 (4 days) shows cell growth inhibitory activity in RS4;11 cells with an IC50 of 5.5 nM, and has no effect on RS4;11/IRMI-2, MDA-MB-231 and MDA-MB-468 cells[1]. |
分子量 | 893.84 |
分子式 | C48H47Cl2FN6O6 |
CAS No. | 2136246-72-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (223.76 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.1188 mL | 5.5938 mL | 11.1877 mL | 27.9692 mL |
5 mM | 0.2238 mL | 1.1188 mL | 2.2375 mL | 5.5938 mL | |
10 mM | 0.1119 mL | 0.5594 mL | 1.1188 mL | 2.7969 mL | |
20 mM | 0.0559 mL | 0.2797 mL | 0.5594 mL | 1.3985 mL | |
50 mM | 0.0224 mL | 0.1119 mL | 0.2238 mL | 0.5594 mL | |
100 mM | 0.0112 mL | 0.0559 mL | 0.1119 mL | 0.2797 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MD-222 2136246-72-3 PROTAC PROTACs MD222 MD 222 Inhibitor inhibitor inhibit