GLP-1(7-36), amide acetate

Name: GLP-1(7-36), amide acetate
Brand: TargetMol
SKU: TP1141
Price: 993 CNY
Availability: InStock
Rating: 5 (10 reviews)

还可以

产品编号 TP1141Cas号 1119517-19-9

别名 胰高血糖素样肽-1（7-36）酰胺醋酸盐, Human GLP-1 (7-36), amide acetate, Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate

GLP-1(7-36), amide acetate（胰高血糖素样肽-1（7-36）酰胺醋酸盐）是GLP-1的衍生物。GLP-1(7-36), amide能够激活GLP-1受体，具有促进胰岛素分泌和抑制胰高血糖素分泌的作用，具有治疗2型糖尿病和肥胖的潜力。

GLP-1(7-36), amide acetate

还可以

纯度: 99.89%

产品编号 TP1141 别名 胰高血糖素样肽-1（7-36）酰胺醋酸盐, Human GLP-1 (7-36), amide acetate, Glucagon-like peptide-1 (GLP-1)(7-36), amide acetateCas号 1119517-19-9

规格	价格	库存
500 μg	¥ 993	In stock
1 mg	¥ 1,650	In stock
5 mg	¥ 4,970	In stock
10 mg	¥ 6,880	In stock
25 mg	¥ 9,870	In stock
50 mg	¥ 13,700	In stock
100 mg	¥ 18,500	In stock

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度:99.89%

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COA HPLC MS 产品操作手册

产品介绍

生物活性

产品描述	GLP-1(7-36), amide acetate is a derivative of GLP-1 peptide (glucagon-like peptide-1).GLP-1(7-36), amide is able to activate the GLP-1 receptor, which has the ability to promote insulin secretion and inhibit glucagon secretion, with the potential to treat type 2 diabetes mellitus and obesity.
体外活性	Cells treated with phorbol 12-myristate 13-acetate for 2 h has significantly higher active GLP-1(7-36) concentrations in the media compares to the control. The glucose treatment also increases active GLP-1 secretion from cells in dose-dependent manner. Palmitic, oleic, linoleic or linolenic acid dose-dependently stimulated active GLP-1 secretion from cells. Active GLP-1 secretion is significantly greater with unsaturated fatty acids such as oleic, linoleic and linolenic acids than with palmitic acid. The treatment of NCI-H716 cells with CPE dose-dependently increases active GLP-1 concentrations in the media. A 37% increase is observed in active GLP-1 secretion from these cells at a concentration of 0.1 % CPE[1].
体内活性	葡萄糖的胃部给药增加了门静脉中的活性 GLP-1(7-36), amide acetate水平 10 分钟后血液，随后活性 GLP-1 水平显着降低 30 分钟。胃部给药 10 分钟后，TO 活性 GLP-1 水平也增加，随后降至 60 分钟时的基础水平。[1]
别名	胰高血糖素样肽-1（7-36）酰胺醋酸盐, Human GLP-1 (7-36), amide acetate, Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate

化学信息

分子量	3357.68
分子式	C₁₅₁H₂₃₀N₄₀O₄₇
CAS No.	1119517-19-9
Smiles	C(C)(O)=O.C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(=N)N)C(N)=O)=O)=O)CCCCN)=O)[C@@H](C)C)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)N)=O)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)C(C)C)=O)CO)=O)CO)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCN)=O)CCC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)C=5C=6C(NC5)=CC=CC6
密度	no data available
Sequence	His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Sequence Short	HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRNH2

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 80.00 mg/mL (23.83 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	0.2978 mL	1.4891 mL	2.9782 mL	14.8912 mL
5 mM	0.0596 mL	0.2978 mL	0.5956 mL	2.9782 mL
10 mM	0.0298 mL	0.1489 mL	0.2978 mL	1.4891 mL
20 mM	0.0149 mL	0.0745 mL	0.1489 mL	0.7446 mL