Elopiprazole

Name: Elopiprazole
Brand: TargetMol
SKU: T68063
Price: 382 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.53%

货号 T68063Cas号 115464-77-2

别名 依吡哌唑, DU 29840

Elopiprazole(DU 29840) 是一种抗神经病化合物，可用来研究神经系统疾病。

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Elopiprazole

一键复制产品信息

很棒

纯度: 99.53%

货号 T68063 别名 依吡哌唑, DU 29840Cas号 115464-77-2

Elopiprazole(DU 29840) 是一种抗神经病化合物，可用来研究神经系统疾病。

规格	价格	库存
1 mg	¥ 382	现货
5 mg	¥ 931	现货
10 mg	¥ 1,400	现货
25 mg	¥ 2,700	现货
50 mg	¥ 3,610	现货
100 mg	¥ 5,630	现货

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纯度: >99.99%

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COA FNMR HNMR LCMS 产品操作手册

产品介绍

Elopiprazole AI Summary

Elopiprazole is a multifaceted bioactive molecule with several notable pharmacological properties. It exhibits a high affinity for the dopamine receptor D2 with a Ki value of 0.45 nM and a moderate binding affinity for the 5-hydroxytryptamine 2 receptors, with a Ki value of 120.0 nM. Additionally, it shows moderate potency in displacing [3H]-WB-4101 from alpha-1 adrenergic receptors (Ki of 220.0 nM) and for the 5-hydroxytryptamine 1A receptor (Ki of 1.5 nM). In behavioral assays, Elopiprazole displays dose-dependent antagonism of apomorphine-induced climbing behavior in mice, with an ED50 of 2.3 mg/kg for both peroral and intraperitoneal administration. It also suppresses conditioned avoidance behavior in rats following oral administration (ED50 = 2.5 mg/kg) and intraperitoneal administration (ED50 = 5.4 mg/kg). However, it only induces catalepsy in rats at a much higher dose, with an ED50 > 54.0 mg/kg intraperitoneally. Moreover, the compound shows antiviral activity against the SARS-CoV-2 virus (USA-WA1/2020 isolate) with an EC50 value of 1100.0 nM after 24 hours in Vero E6 cells, highlighting its potential as an antiviral agent. It also displays a Na+ ratio of 2.0, reflecting its differential activity in the presence of sodium ions. Overall, Elopiprazole has significant potential in both neurological and antiviral therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Elopiprazole(DU 29840) is an anti-neurological compound that can be used to study neurological disorders.
别名	依吡哌唑, DU 29840

化学信息

分子量	375.44
分子式	C₂₃H₂₂FN₃O
CAS No.	115464-77-2
Smiles	C(N1CCN(C2=C3C(=CC=C2)C=CO3)CC1)C=4NC(=CC4)C5=CC=C(F)C=C5

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (133.18 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6635 mL	13.3177 mL	26.6354 mL	133.1771 mL
5 mM	0.5327 mL	2.6635 mL	5.3271 mL	26.6354 mL
10 mM	0.2664 mL	1.3318 mL	2.6635 mL	13.3177 mL
20 mM	0.1332 mL	0.6659 mL	1.3318 mL	6.6589 mL
50 mM	0.0533 mL	0.2664 mL	0.5327 mL	2.6635 mL
100 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3318 mL