ellipticine

Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。

Ellipticine hydrochloride (NSC-71795 (hydrochloride)) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 的活性。

Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-​1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)​. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.

Ellipticine tartrate is a DNA intercalating agent and a DNA topoisomerase II inhibitor.

Di-Ellipticine-RIBOTAC是一款双功能小分子，在体外和体内肌萎缩侧索硬化（ALS）模型中能够减少c9ALS FTD r(G4C2)的重复扩增。

Datelliptium chloride hydrochloride 是一种衍生自玫瑰树碱的 DNA 嵌入剂，具有抗肿瘤活性。

9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found in O. maculataand has anticancer activity.It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 μM, respectively).

9-Hydroxyellipticine hydrochloride 是 Topo II 和 RyR 的抑制剂，具有抗肿瘤、抗氧化、抗心血管和抗白血病活性，抑制角叉菜胶诱导的水肿，可用于研究神经系统疾病和心血管疾病。

Tetrahydroellipticine (1,2,3,4-Tetrahydroellipticin)是一种含有吡啶和咔唑的芳香族化合物，可用于有机合成和药物设计。

Hydroxyellipticine-1a, a selective r(CGG)exp probe, improves pre-mRNA splicing defects, inhibits formation of nuclear inclusions and RANT in a FXTAS cellular mode.l

9-hydroxyellipticine is a potent cytotoxic and antitumor agent. 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine.

K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltrationin vivoand reduces cell adhesion on fibronectin.

Datelliptium chloride 是一种源自玫瑰树碱的 DNA 嵌入剂，具有抗肿瘤活性。