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Bufuralol hydrochloride (Ro 3-4787 hydrochloride) 是一种有效的非选择性,口服活性的 β-肾上腺素受体 (β-adrenoreceptor) 拮抗剂,具有部分激动剂活性。Bufuralol hydrochloride 是CYP2D6 探针的底物。
Bufuralol hydrochloride (Ro 3-4787 hydrochloride) 是一种有效的非选择性,口服活性的 β-肾上腺素受体 (β-adrenoreceptor) 拮抗剂,具有部分激动剂活性。Bufuralol hydrochloride 是CYP2D6 探针的底物。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | 待估 | 35日内发货 | |
5 mg | 待估 | 35日内发货 | |
10 mg | 待估 | 35日内发货 |
产品描述 | Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity, which is also a CYP2D6 probe substrate [1] [2]. |
体外活性 | Bufuralol is widely used in the characterization of CYP2D6 activity. Bufuralol possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates [3]. |
体内活性 | NADPH-mediated metabolism of Bufuralol exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers [4]. |
分子量 | 297.82 |
分子式 | C16H24ClNO2 |
CAS No. | 60398-91-6 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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